{"id":"W4226302906","doi":"10.1093/nar/gkac327","title":"Definition of germ layer cell lineage alternative splicing programs reveals a critical role for Quaking in specifying cardiac cell fate","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Human Genome Research Institute; Canadian Institutes of Health Research; University of Texas Medical Branch","keywords":"Biology; Endoderm; Mesoderm; Germ layer; Cell biology; Alternative splicing; Genetics; RNA splicing; Embryonic stem cell; Ectoderm; RNA-binding protein; Exon; RNA; Gene; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002521382,0.0001985905,0.00016626,0.0003154138,0.0001950282,0.0004188877,0.0001885706,0.0001808478,0.001219057],"category_scores_gemma":[0.0002339343,0.0001541414,0.0002008069,0.0001760428,0.0003627673,0.0003275337,0.0003606841,0.0003592203,0.0003582887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003558857,"about_ca_system_score_gemma":0.0002087093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005566367,"about_ca_topic_score_gemma":0.001291616,"domain_scores_codex":[0.9997999,0.00001698848,0.00002059276,0.00008187379,0.00005623734,0.00002431637],"domain_scores_gemma":[0.9997539,0.00005359825,0.00008033062,0.00004364752,0.0000270187,0.00004146756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002375204,0.000002539547,0.0005844334,0.00001214764,0.000001431593,0.00001471436,0.000008983708,0.0000329556,0.9981719,0.0001397565,0.000007029511,0.001000281],"study_design_scores_gemma":[0.000005409598,0.00006957369,0.03772921,0.000008484269,0.0000128705,0.000398066,0.00004455821,0.002109665,0.95704,0.000432501,0.002139803,0.000009844685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743319,0.001341873,0.0212221,0.0001148966,0.00002550233,0.00002061892,0.0008043644,0.0001297183,0.002008959],"genre_scores_gemma":[0.9877446,0.0005405112,0.009341232,0.00006688437,0.000005549753,0.0000143982,0.0007932077,0.00005093251,0.001442668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001219057,"threshold_uncertainty_score":0.00407815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07768027736427176,"score_gpt":0.3733020986475065,"score_spread":0.2956218212832347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}