{"id":"W4226317345","doi":"10.1093/stcltm/szac022","title":"Maturation Delay of Human GABAergic Neurogenesis in Fragile X Syndrome Pluripotent Stem Cells","year":2022,"lang":"en","type":"article","venue":"Stem Cells Translational Medicine","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Mental Health; National Institutes of Health; National Institute on Drug Abuse; California Institute for Regenerative Medicine","keywords":"Neurogenesis; Fragile X syndrome; Neuroscience; FMR1; Biology; Induced pluripotent stem cell; GABAergic; Inhibitory postsynaptic potential; Gene silencing; Embryonic stem cell; Genetics; Fragile x; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009570926,0.0001260057,0.0002055924,0.0001547156,0.0001133142,0.0002490748,0.00009018978,0.0001192619,0.0004583583],"category_scores_gemma":[0.00009361583,0.0001150331,0.0002199517,0.000163679,0.0001011502,0.0001185288,0.0001638861,0.0002019254,0.0001513079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001691396,"about_ca_system_score_gemma":0.000139925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007527457,"about_ca_topic_score_gemma":0.0009723767,"domain_scores_codex":[0.9999284,0.000004459738,0.000006583477,0.00002366302,0.00002693756,0.00001004647],"domain_scores_gemma":[0.999953,0.00001016839,0.00001482688,0.00000555731,0.000009410988,0.000007037375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004436785,0.000004647865,0.001577977,0.00002777738,0.000007412272,0.00006249548,0.00003979727,0.0001112822,0.9961315,0.00007053276,0.00003890489,0.001883335],"study_design_scores_gemma":[0.00001375056,0.0003264544,0.2128218,0.00002674582,0.00007880053,0.0006777142,0.0001892156,0.002773005,0.7757087,0.0002224434,0.007146589,0.00001469805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933386,0.001229543,0.003208676,0.00002948175,0.00001149726,0.00001591208,0.001360742,0.0000374231,0.0007680823],"genre_scores_gemma":[0.9905489,0.001051522,0.003188947,0.00006466027,0.000007161667,0.00004854927,0.003735379,0.00002218455,0.001332543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007527457,"threshold_uncertainty_score":0.001533389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258694658925087,"score_gpt":0.2224001672303929,"score_spread":0.2098132206411421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}