{"id":"W4226317345","doi":"10.1093/stcltm/szac022","title":"Maturation Delay of Human GABAergic Neurogenesis in Fragile X Syndrome Pluripotent Stem Cells","year":2022,"lang":"en","type":"article","venue":"Stem Cells Translational Medicine","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Mental Health; National Institutes of Health; National Institute on Drug Abuse; California Institute for Regenerative Medicine","keywords":"Neurogenesis; Fragile X syndrome; Neuroscience; FMR1; Biology; Induced pluripotent stem cell; GABAergic; Inhibitory postsynaptic potential; Gene silencing; Embryonic stem cell; Genetics; Fragile x; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836332,0.0001573816,0.000197293,0.0001163113,0.0001032778,0.000003377399,0.0001675077,0.0000532776,0.0001766594],"category_scores_gemma":[6.485134e-7,0.0001587268,0.00006497867,0.0001982374,0.00006303106,0.000003337654,0.00004827179,0.0001025179,0.000002579113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001413366,"about_ca_system_score_gemma":0.0000560451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002185658,"about_ca_topic_score_gemma":0.00002204841,"domain_scores_codex":[0.9985533,0.0001007101,0.0004425693,0.000334885,0.0003913046,0.0001772469],"domain_scores_gemma":[0.9995942,0.00001686997,0.0001167886,0.0001727302,0.00004026416,0.00005918253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006998079,0.0000938123,0.0006001572,0.00004885782,0.00002263591,0.0000201415,0.000203808,0.01007377,0.9879256,0.00004012503,0.000227219,0.000673927],"study_design_scores_gemma":[0.003705632,0.001980965,0.04747438,0.00006312051,0.00006772445,0.00008910654,0.0008469783,0.000821073,0.9349684,0.0001708212,0.009273332,0.0005384564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973207,0.001201219,0.0001601776,0.0003697691,0.0002883618,0.000318285,0.00006039921,0.000006332762,0.0002747583],"genre_scores_gemma":[0.9989319,0.000117054,0.00007000061,0.000180716,0.00001774929,0.00004132717,0.0001858366,0.00002486834,0.0004304959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05295715,"threshold_uncertainty_score":0.647269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258694658925087,"score_gpt":0.2224001672303929,"score_spread":0.2098132206411421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}