{"id":"W4226335310","doi":"10.1093/clinchem/hvac050","title":"Jagged Ends on Multinucleosomal Cell-Free DNA Serve as a Biomarker for Nuclease Activity and Systemic Lupus Erythematosus","year":2022,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Chinese University of Hong Kong; Innovation and Technology Commission","keywords":"Nuclease; DNA; DNA methylation; Molecular biology; Biology; Biomarker; Nucleosome; Micrococcal nuclease; Gene; Genetics; Chromatin; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005238204,0.0002096867,0.0004518568,0.00001993928,0.0001898488,0.00002212473,0.0002241248,0.000204459,0.0001618846],"category_scores_gemma":[0.004529435,0.0001972854,0.0002243359,0.0001103663,0.0001246145,0.00003014298,0.0004220592,0.0005440669,0.00001404108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007084173,"about_ca_system_score_gemma":0.0001067884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001654454,"about_ca_topic_score_gemma":8.18306e-7,"domain_scores_codex":[0.9983739,0.00007250006,0.0004191654,0.0005329709,0.0002958931,0.0003055583],"domain_scores_gemma":[0.9966983,0.00195486,0.0001922636,0.0006660889,0.00006634811,0.0004221788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04650651,0.01272225,0.3159963,0.009368205,0.001015444,0.002932376,0.0004575816,0.00002092561,0.4607901,0.0001138746,0.0953334,0.05474301],"study_design_scores_gemma":[0.1377883,0.01014835,0.08966989,0.002794888,0.002864063,0.01444696,0.003224252,0.03328426,0.6621195,0.001029873,0.03891726,0.003712445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939838,0.0002076909,0.00001911892,0.000645849,0.0002503573,0.0003627351,0.0002660118,0.0001295152,0.004134923],"genre_scores_gemma":[0.9970781,0.00001639133,0.0002020741,0.0004547668,0.000242889,0.0001020203,0.00007418254,0.00004330601,0.001786251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2263264,"threshold_uncertainty_score":0.8045067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03739913750380219,"score_gpt":0.323680712766085,"score_spread":0.2862815752622828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}