{"id":"W4226335310","doi":"10.1093/clinchem/hvac050","title":"Jagged Ends on Multinucleosomal Cell-Free DNA Serve as a Biomarker for Nuclease Activity and Systemic Lupus Erythematosus","year":2022,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Chinese University of Hong Kong; Innovation and Technology Commission","keywords":"Nuclease; DNA; DNA methylation; Molecular biology; Biology; Biomarker; Nucleosome; Micrococcal nuclease; Gene; Genetics; Chromatin; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000394278,0.0003449288,0.0001882494,0.0009822367,0.0001588875,0.0003302601,0.0001636242,0.0004774812,0.001546524],"category_scores_gemma":[0.0004768403,0.0001266139,0.0001626823,0.0004015369,0.0002635417,0.0002114357,0.0002746987,0.0003130175,0.0003256093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001976483,"about_ca_system_score_gemma":0.0000825735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002419683,"about_ca_topic_score_gemma":0.0003232839,"domain_scores_codex":[0.9997433,0.00005797613,0.00002556231,0.00008235082,0.00005936707,0.00003152931],"domain_scores_gemma":[0.9993017,0.0001435508,0.0003511156,0.00004915524,0.0000597447,0.00009480217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006445782,0.00004038657,0.04424842,0.0001568619,0.00005488296,0.0002292885,0.00008847036,0.0001179604,0.9474412,0.0001080943,0.0001060208,0.006763837],"study_design_scores_gemma":[0.00004490755,0.0009580186,0.4477717,0.00008514954,0.000180856,0.005090937,0.0002188737,0.002024943,0.5380701,0.0007751116,0.004753138,0.00002628323],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872718,0.006398247,0.004499557,0.00006972939,0.00001674624,0.00002447377,0.0007332142,0.00009299996,0.0008931155],"genre_scores_gemma":[0.9941412,0.0008452415,0.00365659,0.0000565898,0.00001064042,0.00002438869,0.000503371,0.00001388826,0.0007479902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001546524,"threshold_uncertainty_score":0.005173683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03739913750380219,"score_gpt":0.323680712766085,"score_spread":0.2862815752622828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}