{"id":"W4226354766","doi":"10.4049/immunohorizons.2100111","title":"The E26 Transformation–Specific Family Transcription Factor Spi-C Is Dynamically Regulated by External Signals in B Cells","year":2022,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"","keywords":"Transcription factor; Downregulation and upregulation; Biology; Transcription (linguistics); Cell biology; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003550204,0.000212333,0.0001638879,0.00006137823,0.0004299476,0.00007585419,0.000501112,0.0001194108,0.000132182],"category_scores_gemma":[0.000006530113,0.0001941799,0.0001665545,0.0002110555,0.00008993996,0.00001133512,0.00005636446,0.0003227108,0.00001961381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009619026,"about_ca_system_score_gemma":0.00008066821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006108826,"about_ca_topic_score_gemma":0.00001222835,"domain_scores_codex":[0.9982405,0.0002166459,0.0004699022,0.0003505111,0.0003377189,0.0003847438],"domain_scores_gemma":[0.9993252,0.00002816167,0.0001039426,0.0004304884,0.00005553999,0.00005668489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001814503,0.00009090785,0.00002529417,0.000004657433,0.00003825955,0.000002778665,0.0004169881,0.0004033828,0.9924763,0.00006032106,0.001991072,0.004308601],"study_design_scores_gemma":[0.001057906,0.000557797,0.0007783037,0.00001478378,0.00001545898,0.00001301152,0.0005645218,0.0005005953,0.8806885,0.0001942533,0.1152742,0.0003407193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879977,0.004782159,0.005021286,0.0004059191,0.0004877687,0.0004214977,0.0005267886,0.00003077498,0.0003261502],"genre_scores_gemma":[0.9980515,0.0005245809,0.0001026428,0.0001878,0.00005161011,0.0001066211,0.0002330307,0.00003839846,0.0007038258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1132831,"threshold_uncertainty_score":0.7918428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009398247262218383,"score_gpt":0.2204148519606783,"score_spread":0.2110166046984599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}