{"id":"W4226375045","doi":"10.1039/d1md00070e","title":"Identification of ligand linkage vectors for the development of p300/CBP degraders","year":2022,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Children's Hospital Foundation","keywords":"Linker; Moiety; Ligand (biochemistry); Chemistry; Combinatorial chemistry; Small molecule; Linkage (software); Conjugate; Stereochemistry; Computational biology; Target protein; DNA ligase; Ubiquitin ligase; Biochemistry; Biology; Computer science; DNA; Ubiquitin; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009171487,0.0007440187,0.0004435779,0.0007649948,0.0002076719,0.0007579604,0.0005303141,0.000632443,0.001784796],"category_scores_gemma":[0.0007574138,0.0004294603,0.0005449989,0.0003997443,0.0003198799,0.0004793929,0.0003987312,0.001392048,0.001864112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000687646,"about_ca_system_score_gemma":0.0005140043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000515877,"about_ca_topic_score_gemma":0.0006590456,"domain_scores_codex":[0.9994634,0.00009975139,0.00007438295,0.00007517613,0.0001982029,0.00008907603],"domain_scores_gemma":[0.9995141,0.0001110889,0.0001185545,0.00005481357,0.00007995097,0.0001214928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001312653,0.00009403117,0.00009180985,0.00007286081,0.000008268357,0.00008424649,0.00002121884,0.000195623,0.9929287,0.0006425693,0.0001872421,0.005542158],"study_design_scores_gemma":[0.00002941066,0.0002675934,0.0002339902,0.000008097485,0.00001592633,0.0001705469,0.00001072155,0.0006951219,0.9931723,0.00005948464,0.005328442,0.000008362132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4786155,0.003344554,0.5017231,0.000721457,0.0002460566,0.002688769,0.003471235,0.00307414,0.006115139],"genre_scores_gemma":[0.6608104,0.003418622,0.3074221,0.0002134707,0.00005617291,0.001389729,0.009359225,0.0005791452,0.01675113],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001784796,"threshold_uncertainty_score":0.005970776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410471173838494,"score_gpt":0.2574947626027377,"score_spread":0.2433900508643528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}