{"id":"W4226389230","doi":"10.3389/fendo.2022.881309","title":"Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function","year":2022,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Transcription factor; Biology; Leydig cell; Cellular differentiation; Gene; Cell biology; Regulation of gene expression; Transcription (linguistics); Embryonic stem cell; Cell fate determination; Gene expression; TCF4; Cell type; Psychological repression; Cell; Genetics; Endocrinology; Luteinizing hormone; Enhancer; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003349115,0.000632058,0.0008965578,0.001381782,0.0002132768,0.0008356431,0.0005842508,0.0005611147,0.004360467],"category_scores_gemma":[0.0004471178,0.0001769715,0.0003254774,0.001671673,0.0003024176,0.0007926981,0.0004477258,0.001124959,0.0028267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004667341,"about_ca_system_score_gemma":0.0008949498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006282311,"about_ca_topic_score_gemma":0.001113403,"domain_scores_codex":[0.9998741,0.00001867402,0.00001660094,0.00002043277,0.00005489715,0.00001520536],"domain_scores_gemma":[0.9998444,0.0000724053,0.00002072797,0.000003956788,0.00004186284,0.00001655847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001037996,0.00004720419,0.0002573043,0.01643735,0.00009355196,0.0002917339,0.00007404324,0.0003671126,0.00445798,0.003927513,0.03687802,0.9370645],"study_design_scores_gemma":[0.000008543135,0.00004627404,0.000764823,0.001685034,0.00007843207,0.0008937995,0.00003993357,0.00004814975,0.0007715121,0.001430518,0.9942204,0.00001265797],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001323328,0.9981218,0.0001505546,0.0001543449,0.0002013675,0.000003557584,0.00003584056,0.00001284307,0.001187388],"genre_scores_gemma":[0.0005902626,0.9982013,0.0001762877,0.00009815893,0.000140233,0.000005053431,0.0000617117,0.00000225897,0.0007248596],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004360467,"threshold_uncertainty_score":0.01458722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02615880071095241,"score_gpt":0.2674487308782714,"score_spread":0.241289930167319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}