{"id":"W4226424068","doi":"10.1186/s13063-022-06219-7","title":"A multicenter, open-label, randomized, proof-of-concept phase II clinical trial to assess the efficacy and safety of icatibant in patients infected with SARS-CoV-2 (COVID-19) and admitted to hospital units without invasive mechanical ventilation: study protocol (ICAT-COVID)","year":2022,"lang":"en","type":"article","venue":"Trials","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universitat de Barcelona; Centres de Recerca de Catalunya; Generalitat de Catalunya; Canadian Institute for Theoretical Astrophysics","keywords":"Medicine; Icatibant; Randomized controlled trial; Randomization; Cytokine storm; Clinical trial; Internal medicine; Off-label use; Pneumonia; Coronavirus disease 2019 (COVID-19); Intensive care medicine; Infectious disease (medical specialty); Bradykinin; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005274507,0.004339845,0.004185492,0.0007714402,0.001122329,0.001627812,0.002139261,0.00390653,0.01141504],"category_scores_gemma":[0.003197935,0.001235765,0.001772899,0.0006503977,0.002272385,0.001712059,0.0007432908,0.004837084,0.00205241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001174112,"about_ca_system_score_gemma":0.004878787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006065143,"about_ca_topic_score_gemma":0.001745372,"domain_scores_codex":[0.9983327,0.0008471368,0.00009191379,0.0002540117,0.0001447714,0.0003295564],"domain_scores_gemma":[0.9973462,0.0004585268,0.0006538946,0.0002143529,0.0002632749,0.001063813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9573107,0.02970906,0.0003513246,0.0004693625,0.0002890064,0.00003889783,0.00004315887,0.0003479255,0.004856536,0.000118371,0.001125416,0.005340429],"study_design_scores_gemma":[0.9064105,0.09187148,0.0004833586,0.00001912012,0.0001014815,0.00001854544,0.000009664901,0.0001926096,0.0003559799,0.00007660218,0.0004511654,0.000009498967],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8494045,0.003013493,0.003217059,0.002036734,0.001490644,0.1306766,0.005656767,0.0003728184,0.004131357],"genre_scores_gemma":[0.7403126,0.002924403,0.01363422,0.004600544,0.001488026,0.2238349,0.006043413,0.00008237685,0.007079502],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01141504,"threshold_uncertainty_score":0.03818709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4015424654767214,"score_gpt":0.5733146399548996,"score_spread":0.1717721744781782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}