{"id":"W4226439324","doi":"10.20944/preprints202204.0077.v1","title":"Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signalling and TYK2-Mediated STAT3 Signalling Pathways <em>In Vitro</em>","year":2022,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Mitacs","keywords":"Inflammasome; Cytokine; Proinflammatory cytokine; Signal transduction; Pharmacology; Inflammation; Immunology; Biology; Chemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002742291,0.001086195,0.0009963175,0.0003245798,0.0005882314,0.0001300591,0.001496084,0.0008372158,0.000329391],"category_scores_gemma":[0.0006923764,0.001062304,0.0004679269,0.0003670653,0.0001765348,0.00003416996,0.004433138,0.002101219,0.00009051913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002691872,"about_ca_system_score_gemma":0.0006121978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004734626,"about_ca_topic_score_gemma":0.0007911759,"domain_scores_codex":[0.9935681,0.0007024203,0.001541141,0.002090108,0.0008248163,0.001273389],"domain_scores_gemma":[0.9965933,0.0001398151,0.0009919261,0.00167881,0.0003536525,0.0002425046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004631957,0.0001382748,0.01637236,0.0002287711,0.0004429164,0.00005974469,0.00323815,0.006634229,0.9701617,0.00001834294,0.00002543297,0.002216849],"study_design_scores_gemma":[0.00286984,0.0002844508,0.04259166,0.0002769209,0.0002406071,0.00002661039,0.002835741,0.004413199,0.9335007,0.0005269279,0.01006379,0.002369555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993919,0.002232897,0.0003189975,0.0003934726,0.000602776,0.001632731,0.0001612906,0.0001134597,0.0006254074],"genre_scores_gemma":[0.9942343,0.001632638,0.0001486839,0.0003663174,0.0004202823,0.0007591721,0.001836782,0.0002068179,0.0003950258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03666104,"threshold_uncertainty_score":0.9991827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03698347747171811,"score_gpt":0.268248722182487,"score_spread":0.2312652447107689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}