{"id":"W4226439324","doi":"10.20944/preprints202204.0077.v1","title":"Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signalling and TYK2-Mediated STAT3 Signalling Pathways <em>In Vitro</em>","year":2022,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Mitacs","keywords":"Inflammasome; Cytokine; Proinflammatory cytokine; Signal transduction; Pharmacology; Inflammation; Immunology; Biology; Chemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486982,0.000440592,0.0005807459,0.0003197884,0.0002492594,0.0002443078,0.0002507377,0.0003276939,0.002282069],"category_scores_gemma":[0.0001235427,0.0001724921,0.0005334627,0.0002072798,0.0003156243,0.0003389655,0.0002620196,0.001149599,0.0004761363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003041061,"about_ca_system_score_gemma":0.0005372487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001499181,"about_ca_topic_score_gemma":0.003433904,"domain_scores_codex":[0.9998392,0.00002034421,0.00002275634,0.00001951363,0.00003517411,0.00006306134],"domain_scores_gemma":[0.9999332,0.000007404707,0.00001549571,0.000007015385,0.000008679605,0.00002817247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004833747,0.0007066361,0.0002796676,0.0003515533,0.00002818783,0.0001802954,0.00006055455,0.0001389133,0.987217,0.0001698374,0.0002913579,0.005742229],"study_design_scores_gemma":[0.0006435764,0.005314121,0.008262097,0.00004545252,0.0001081396,0.000337385,0.0001468351,0.001741279,0.9773941,0.0002534667,0.005729027,0.00002442071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876361,0.006565883,0.001450084,0.0005305427,0.0002351224,0.00007873686,0.0008214339,0.0001306725,0.002551449],"genre_scores_gemma":[0.9874614,0.003333748,0.002198525,0.0003169156,0.00005412503,0.0001252628,0.000880256,0.00002596271,0.005603699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002282069,"threshold_uncertainty_score":0.007634342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03698347747171811,"score_gpt":0.268248722182487,"score_spread":0.2312652447107689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}