{"id":"W4229001753","doi":"10.1016/j.jchf.2022.03.004","title":"Increase in BNP in Response to Endothelin-Receptor Antagonist Atrasentan Is Associated With Incident Heart Failure","year":2022,"lang":"en","type":"article","venue":"JACC Heart Failure","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Horizon 2020 Framework Programme; National Institutes of Health; Innovative Medicines Initiative; Boehringer Ingelheim; Janssen Pharmaceuticals; Gilead Sciences; Novartis; Bayer; Abbott Diagnostics; AstraZeneca; Novo Nordisk; European Federation of Pharmaceutical Industries and Associations; AbbVie; Merck; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Astellas Pharma US","keywords":"Medicine; Internal medicine; Placebo; Heart failure; Diabetes mellitus; Kidney disease; Renal function; Urology; Cardiology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001462803,0.0003309406,0.00084142,0.000115956,0.0001376158,0.0003595851,0.0002656853,0.000356715,0.001349673],"category_scores_gemma":[0.001304847,0.0001889749,0.0006668541,0.0001501773,0.0001922242,0.0002183445,0.0001800235,0.0009521817,0.0001142803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001709535,"about_ca_system_score_gemma":0.00023107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002356925,"about_ca_topic_score_gemma":0.0004421555,"domain_scores_codex":[0.9995509,0.0001973054,0.00003381899,0.00007896185,0.00009421385,0.00004468443],"domain_scores_gemma":[0.9989246,0.0002806013,0.0004959503,0.00006628594,0.00005402207,0.0001784822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2297725,0.003964053,0.6414777,0.0006948662,0.003806623,0.0004279738,0.0001153644,0.001125375,0.05528264,0.0001467762,0.0009671397,0.062219],"study_design_scores_gemma":[0.005705128,0.01799155,0.9690177,0.00004366817,0.001405225,0.0004594833,0.00003583874,0.001038874,0.003516471,0.0001311542,0.0006345694,0.00002048275],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997781,0.001367011,0.0001960957,0.00006840404,0.00002684553,0.00003437351,0.0001317156,0.000009921411,0.0003846481],"genre_scores_gemma":[0.9987482,0.0004797537,0.0002414041,0.00009809232,0.00005784799,0.00002911944,0.0001581451,0.000002357304,0.000185014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001462803,"threshold_uncertainty_score":0.007736146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008999145967061167,"score_gpt":0.2590471697142852,"score_spread":0.250048023747224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}