{"id":"W4229001753","doi":"10.1016/j.jchf.2022.03.004","title":"Increase in BNP in Response to Endothelin-Receptor Antagonist Atrasentan Is Associated With Incident Heart Failure","year":2022,"lang":"en","type":"article","venue":"JACC Heart Failure","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Horizon 2020 Framework Programme; National Institutes of Health; Innovative Medicines Initiative; Boehringer Ingelheim; Janssen Pharmaceuticals; Gilead Sciences; Novartis; Bayer; Abbott Diagnostics; AstraZeneca; Novo Nordisk; European Federation of Pharmaceutical Industries and Associations; AbbVie; Merck; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Astellas Pharma US","keywords":"Medicine; Internal medicine; Placebo; Heart failure; Diabetes mellitus; Kidney disease; Renal function; Urology; Cardiology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002081586,0.0004060486,0.0008571225,0.0008089468,0.0002270889,0.00005345176,0.0002116198,0.000177279,0.00183104],"category_scores_gemma":[0.0009169215,0.0003774034,0.0001697828,0.001796078,0.00006302078,0.0001403531,0.0002112797,0.001143941,0.0003152993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001075336,"about_ca_system_score_gemma":0.0006377867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002275828,"about_ca_topic_score_gemma":0.002958272,"domain_scores_codex":[0.9958069,0.00104716,0.0006208288,0.0007314325,0.0009373893,0.0008562523],"domain_scores_gemma":[0.9979442,0.0007225968,0.0001082284,0.0006236443,0.00009376182,0.0005075657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009539453,0.001116885,0.5885908,0.00006907061,0.00008270388,0.001146028,0.001932601,0.0001316384,0.2498796,0.00001139149,0.1473111,0.0001887641],"study_design_scores_gemma":[0.01803358,0.004335701,0.3160134,0.0007100048,0.0001123557,0.0008438525,0.005817822,0.0001668375,0.02116994,0.00003346391,0.631694,0.001069054],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9443185,0.0001007222,0.000004166201,0.05348508,0.0001253674,0.001492285,0.0002791536,0.0001239408,0.0000707923],"genre_scores_gemma":[0.9839221,0.000003601802,0.002063926,0.01186381,0.0001648551,0.0003700099,0.0001212247,0.0000963337,0.001394172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4843829,"threshold_uncertainty_score":0.9998678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008999145967061167,"score_gpt":0.2590471697142852,"score_spread":0.250048023747224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}