{"id":"W4229007609","doi":"10.1161/circgen.121.003575","title":"Genetically Predicted Pulse Pressure and Risk of Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis","year":2022,"lang":"en","type":"letter","venue":"Circulation Genomic and Precision Medicine","topic":"Aortic aneurysm repair treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Heart, Lung, and Blood Institute; National Institute on Aging; U.S. Department of Veterans Affairs; National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust","keywords":"Biostatistics; Mendelian randomization; Abdominal aortic aneurysm; Medicine; Public health; Epidemiology; Family medicine; Gerontology; Internal medicine; Surgery; Aneurysm; Genetics; Nursing; Biology; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008370311,0.000487024,0.001616767,0.0009464204,0.0001995811,0.00001767341,0.0001397363,0.0006234631,0.002560843],"category_scores_gemma":[0.0008925675,0.0003908686,0.0002450585,0.0006985753,0.0003686341,0.00006272548,0.0001249527,0.001103583,0.000002606909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008959564,"about_ca_system_score_gemma":0.00013926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001525156,"about_ca_topic_score_gemma":0.000002083591,"domain_scores_codex":[0.9955705,0.000656728,0.001430513,0.0009578473,0.00104676,0.0003376365],"domain_scores_gemma":[0.9967884,0.0009659984,0.001015524,0.0007584171,0.0002598197,0.0002117895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009830341,0.0003616016,0.6392179,0.0025862,0.0270161,0.002444132,0.00405994,0.005982578,0.00466921,0.00001019448,0.2483056,0.05551624],"study_design_scores_gemma":[0.02093211,0.001811458,0.6574516,0.0002848697,0.1002136,0.001003713,0.0001513109,0.1734551,0.00002331259,0.0003932777,0.0436173,0.0006623381],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7521919,0.01205264,0.02160608,0.2074166,0.0004693483,0.004941279,0.0005520181,0.0001922407,0.0005779048],"genre_scores_gemma":[0.9100569,0.003758534,0.001496494,0.0777484,0.001339924,0.0001419861,0.003885505,0.0001234869,0.001448695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2046883,"threshold_uncertainty_score":0.9998543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0127499026437916,"score_gpt":0.2563889409132377,"score_spread":0.2436390382694461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}