{"id":"W4229010457","doi":"10.1038/s41588-022-01057-4","title":"Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis","year":2022,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":323,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Mental Health; National Institute on Aging; Medical Research Council; H. Lundbeck A/S; Horizon 2020 Framework Programme; Novo Nordisk Fonden; Lundbeckfonden; Jacobs Foundation; ZonMw; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Aarhus Universitet; European Commission; Novo Nordisk; National Institute for Health and Care Research; National Institutes of Health; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Fritz Thyssen Stiftung; South London and Maudsley NHS Foundation Trust; Deutsche Forschungsgemeinschaft; King's College London; UK Research and Innovation","keywords":"Genetic architecture; Biology; Genetics; Genome-wide association study; Genetic association; Psychiatric genetics; Gene; Schizophrenia (object-oriented programming); Psychology; Psychiatry; Single-nucleotide polymorphism; Phenotype; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001207239,0.000672663,0.0004914796,0.001387745,0.0005579508,0.0006079673,0.0003758268,0.0003890411,0.002024725],"category_scores_gemma":[0.003310679,0.0003538577,0.0009723596,0.001184187,0.0008653665,0.000222518,0.001097275,0.0005862684,0.0001058335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005124816,"about_ca_system_score_gemma":0.0008512691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00656512,"about_ca_topic_score_gemma":0.01022233,"domain_scores_codex":[0.9981129,0.0007744071,0.000121839,0.000547756,0.0002782413,0.0001649453],"domain_scores_gemma":[0.9979656,0.0007400695,0.0008268254,0.0001846742,0.0001231317,0.0001597514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004282205,0.0000549471,0.9754941,0.00002453324,0.000534535,0.0003903487,0.0002090432,0.001625027,0.01182119,0.0009764647,0.00009993129,0.008341626],"study_design_scores_gemma":[0.00002632882,0.0001558894,0.9907082,0.00001541528,0.0003346351,0.0007395035,0.0001277034,0.005016244,0.001228617,0.001484198,0.0001471213,0.00001617502],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975863,0.0001036459,0.00178913,0.00007253005,0.00000170614,0.00001100697,0.0001420347,0.00001415272,0.0002796378],"genre_scores_gemma":[0.9980559,0.00006102186,0.001617821,0.00001695699,0.00000281635,0.00001049604,0.0001391912,0.000005284298,0.000090455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00656512,"threshold_uncertainty_score":0.01305383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006317861469321294,"score_gpt":0.2427705081908925,"score_spread":0.2364526467215712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}