{"id":"W4229011120","doi":"10.1038/s41598-022-08441-4","title":"In vitro assessment of skin sensitization, irritability and toxicity of bacteriocins and reuterin for possible topical applications","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; International Development Research Centre","keywords":"Bacteriocin; Nisin; Hand sanitizer; Sensitization; Chemistry; Toxicity; In vitro; Cathelicidin; Microbiology; Pharmacology; Human skin; Antimicrobial peptides; Antimicrobial; Food science; Medicine; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002644337,0.0005009155,0.0003072105,0.0002446754,0.0001455808,0.0002376593,0.0001676695,0.0002919437,0.001069643],"category_scores_gemma":[0.0002039278,0.000116989,0.0003019497,0.0002063735,0.000147444,0.000228608,0.000170851,0.000389029,0.0001367816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001535396,"about_ca_system_score_gemma":0.0001472879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000494648,"about_ca_topic_score_gemma":0.0006840784,"domain_scores_codex":[0.9997886,0.00004823166,0.00001957596,0.00003815118,0.00007422629,0.00003122882],"domain_scores_gemma":[0.9998025,0.00006940284,0.00005039303,0.0000160601,0.00003937299,0.00002232257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006655839,0.00004043274,0.00009202207,0.00005835238,0.000003010713,0.00002395649,0.00001152804,0.000051154,0.9989742,0.000008325105,0.000007250442,0.000663342],"study_design_scores_gemma":[0.000006349563,0.001118161,0.002382061,0.00001235016,0.00001965896,0.00006409041,0.00004248797,0.0003718213,0.9953441,0.00001257236,0.000622682,0.000003553388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909832,0.004214068,0.002695397,0.00005632017,0.00003908207,0.00009744923,0.0001954515,0.00002723772,0.001691704],"genre_scores_gemma":[0.9920911,0.002235968,0.003283032,0.0000373813,0.00001444221,0.00007190086,0.0001726064,0.00001056038,0.002083025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001069643,"threshold_uncertainty_score":0.003578305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009050325753004523,"score_gpt":0.2588623888651101,"score_spread":0.2498120631121056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}