{"id":"W4229013347","doi":"10.1182/blood.2021014956","title":"Lenalidomide promotes the development of <i>TP53</i>-mutated therapy-related myeloid neoplasms","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Health Sciences Centre; University Health Network; Sunnybrook Health Science Centre","funders":"National Cancer Institute; University of Texas MD Anderson Cancer Center; National Heart, Lung, and Blood Institute; National Institutes of Health; Andrew Sabin Family Foundation; Edward P. Evans Foundation; Howard Hughes Medical Institute; Cancer Prevention and Research Institute of Texas; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Welch Foundation; University of Texas System; Leukemia and Lymphoma Society","keywords":"Lenalidomide; Progenitor cell; Haematopoiesis; Thalidomide; Myeloid; Cancer research; Biology; Pomalidomide; Stem cell; Immunology; Multiple myeloma; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479537,0.00016442,0.0002161546,0.0002255311,0.0001118523,0.0004010507,0.00009992813,0.000172151,0.001430894],"category_scores_gemma":[0.000219545,0.00008924477,0.0001691507,0.0001149568,0.00009291378,0.0001169792,0.0002015723,0.0003600755,0.0003338312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002109223,"about_ca_system_score_gemma":0.0001968643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005279185,"about_ca_topic_score_gemma":0.0009956477,"domain_scores_codex":[0.999843,0.00004024119,0.0000135546,0.00001911545,0.00003675267,0.00004728786],"domain_scores_gemma":[0.9998066,0.00003015328,0.00005325135,0.00002485914,0.00001543749,0.00006963418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003815299,0.0007284195,0.01823221,0.0001375363,0.00005826456,0.0009278845,0.0000826117,0.0004690779,0.9401537,0.0005088453,0.0008409093,0.0340452],"study_design_scores_gemma":[0.0002553055,0.006214841,0.2083652,0.00004419794,0.0001456633,0.0030149,0.0001985476,0.002426708,0.7434922,0.0003052827,0.03552198,0.00001517579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934277,0.002652881,0.0004843295,0.00007125074,0.00002597961,0.00004009823,0.0001870852,0.00006963248,0.003041187],"genre_scores_gemma":[0.9973551,0.0007921403,0.0002996429,0.00005528983,0.00001218535,0.00001156615,0.0001585334,0.000007834044,0.001307725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430894,"threshold_uncertainty_score":0.004786849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093353391674051,"score_gpt":0.2662075918491015,"score_spread":0.245274057932361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}