{"id":"W4229013624","doi":"10.1021/acssynbio.2c00062","title":"Genome Engineering of the Fast-Growing <i>Mycoplasma feriruminatoris</i> toward a Live Vaccine Chassis","year":2022,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Agence Nationale de la Recherche","keywords":"Biology; Mycoplasma; Chassis; Genome; Heterologous; Genome engineering; Microbiology; Genetics; Cas9; Virology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003206753,0.000161769,0.000299432,0.0001403742,0.0003614961,0.000006081192,0.000439792,0.0001434485,0.001652572],"category_scores_gemma":[0.0001160583,0.0001242422,0.0001683661,0.0003004453,0.0001308511,0.00003376051,0.0007197334,0.0004440315,0.0001391694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008644628,"about_ca_system_score_gemma":0.00009532819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001832461,"about_ca_topic_score_gemma":0.000004821362,"domain_scores_codex":[0.9986194,0.000331065,0.0002856031,0.0002990876,0.00003589336,0.0004289276],"domain_scores_gemma":[0.999224,0.0001938463,0.0001033721,0.0003946422,0.00005637938,0.0000277392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000578363,0.0001267508,0.001372415,0.00002563838,0.0001579304,0.000002205009,0.0003374075,0.0001349742,0.9949191,0.001572175,0.0001864828,0.001107137],"study_design_scores_gemma":[0.00217938,0.0008922424,0.004677862,0.0000513931,0.0002170246,0.001193143,0.001912806,0.00005634273,0.700926,0.0004829708,0.2867388,0.0006720197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951735,0.002083611,0.0001142476,0.0008476037,0.001005773,0.000268448,0.0002006197,0.00004958422,0.0002565724],"genre_scores_gemma":[0.9992524,0.0000787661,0.00001387579,0.000105793,0.00002783069,0.0001016099,0.00004100202,0.00001924516,0.0003595084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.293993,"threshold_uncertainty_score":0.9992601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009640660185008677,"score_gpt":0.2239954250142509,"score_spread":0.2143547648292422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}