{"id":"W4229013624","doi":"10.1021/acssynbio.2c00062","title":"Genome Engineering of the Fast-Growing <i>Mycoplasma feriruminatoris</i> toward a Live Vaccine Chassis","year":2022,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Agence Nationale de la Recherche","keywords":"Biology; Mycoplasma; Chassis; Genome; Heterologous; Genome engineering; Microbiology; Genetics; Cas9; Virology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000179994,0.0004145567,0.0001568022,0.0002179896,0.000211584,0.0004103786,0.0003612861,0.0003198369,0.0008076683],"category_scores_gemma":[0.0001551193,0.0001429639,0.0002648359,0.0002513627,0.0001759978,0.0002110035,0.0002926594,0.0006012953,0.0004183278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003757534,"about_ca_system_score_gemma":0.0003285736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002288214,"about_ca_topic_score_gemma":0.003469657,"domain_scores_codex":[0.9998964,0.00001615702,0.000008000776,0.00001869998,0.00003289311,0.00002779213],"domain_scores_gemma":[0.9999279,0.00001048283,0.00002948005,0.000008232428,0.0000120471,0.0000119692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003348072,0.00001470566,0.00007791104,0.00003231773,0.000002919535,0.00003287739,0.00002078604,0.0001604462,0.9975388,0.0004051541,0.0001200826,0.001560365],"study_design_scores_gemma":[0.00001242465,0.0001508286,0.001296827,0.00001566273,0.00001770748,0.0002715254,0.00006129241,0.001905376,0.9827305,0.0002032421,0.01332329,0.00001132472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539142,0.001670838,0.03371208,0.0006448635,0.0001777194,0.0001457397,0.0021439,0.0005043027,0.007086363],"genre_scores_gemma":[0.9635177,0.00102808,0.02721504,0.0001187717,0.00001447929,0.00004787042,0.002674666,0.0001569425,0.005226363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002288214,"threshold_uncertainty_score":0.004549801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009640660185008677,"score_gpt":0.2239954250142509,"score_spread":0.2143547648292422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}