{"id":"W4229015799","doi":"10.25251/skin.6.supp.7","title":"Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Efficacy by Baseline Disease Characteristics and Demographics in Two Pivotal Phase 3 Trials","year":2022,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Phytochemistry Medicinal Plant Applications","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Allergan; Genentech; Astellas Pharma; Glenmark Pharmaceuticals; Pfizer; Biogen; Incyte; Sun Pharma; Dermira; Coherus Biosciences; Valeant Pharmaceuticals International; Ablynx; Celgene; Novartis; GlaxoSmithKline; Astellas Pharma US; Amgen; Galderma; LEO Pharma; Ortho Dermatologics; Eli Lilly and Company; Bristol-Myers Squibb; Bausch Health; Bayer HealthCare; Sanofi; Regeneron Pharmaceuticals; Abbott Laboratories","keywords":"Demographics; Plaque psoriasis; Medicine; Baseline (sea); Psoriasis; Internal medicine; Disease; Dermatology; Demography; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00329624,0.0001624797,0.0005260344,0.00002759857,0.0002795998,0.00001192659,0.0003955787,0.00002797096,0.0001553561],"category_scores_gemma":[0.002343574,0.0000593564,0.00009112532,0.0003254935,0.0001747461,0.00003957399,0.00005340308,0.0003958446,3.012811e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004077234,"about_ca_system_score_gemma":0.00003938626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002683801,"about_ca_topic_score_gemma":0.00002016521,"domain_scores_codex":[0.9979079,0.0003910881,0.0008561973,0.0001609935,0.0004618666,0.0002219746],"domain_scores_gemma":[0.9937323,0.005081606,0.0007558183,0.00008133778,0.0001074868,0.0002414267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01569113,0.002478412,0.001455786,0.00006976304,0.0001656444,0.0004718925,0.0007467575,0.0001129342,0.8054187,0.00009701169,0.0678423,0.1054497],"study_design_scores_gemma":[0.05720104,0.03344912,0.01324863,0.002446003,0.005146097,0.03282736,0.01700373,0.01015745,0.01093515,0.0104106,0.8047138,0.002461015],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805,0.002247247,0.0001199826,0.0155763,0.0001918101,0.0005280486,0.0008054625,0.000009832012,0.000021287],"genre_scores_gemma":[0.9967528,0.001093308,0.00003657268,0.0005788913,0.001188988,0.0000304547,0.000248061,0.000002428528,0.00006848008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7944835,"threshold_uncertainty_score":0.2805647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02959360416677615,"score_gpt":0.3188886737373182,"score_spread":0.289295069570542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}