{"id":"W4229015799","doi":"10.25251/skin.6.supp.7","title":"Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Efficacy by Baseline Disease Characteristics and Demographics in Two Pivotal Phase 3 Trials","year":2022,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Phytochemistry Medicinal Plant Applications","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Allergan; Genentech; Astellas Pharma; Glenmark Pharmaceuticals; Pfizer; Biogen; Incyte; Sun Pharma; Dermira; Coherus Biosciences; Valeant Pharmaceuticals International; Ablynx; Celgene; Novartis; GlaxoSmithKline; Astellas Pharma US; Amgen; Galderma; LEO Pharma; Ortho Dermatologics; Eli Lilly and Company; Bristol-Myers Squibb; Bausch Health; Bayer HealthCare; Sanofi; Regeneron Pharmaceuticals; Abbott Laboratories","keywords":"Demographics; Plaque psoriasis; Medicine; Baseline (sea); Psoriasis; Internal medicine; Disease; Dermatology; Demography; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002204566,0.0014728,0.002645933,0.0005019768,0.0004663446,0.001076041,0.0008699367,0.00128514,0.007748176],"category_scores_gemma":[0.001258037,0.0006748642,0.002351372,0.0005275614,0.0007551468,0.0009753681,0.0003172162,0.002817172,0.001118342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006359463,"about_ca_system_score_gemma":0.0009228037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022141,"about_ca_topic_score_gemma":0.003394576,"domain_scores_codex":[0.9993836,0.000261942,0.00003943073,0.0001026114,0.00008317202,0.0001292113],"domain_scores_gemma":[0.9993688,0.0001832488,0.0001474964,0.00005303569,0.00005178801,0.0001955702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8565896,0.01621122,0.001981788,0.001743008,0.002186645,0.00009421909,0.0001357869,0.0007438634,0.01641089,0.0002335234,0.004227444,0.09944198],"study_design_scores_gemma":[0.8521642,0.1325435,0.00990568,0.0001195208,0.001248886,0.0001051683,0.00004138961,0.0004218046,0.000917325,0.0002262824,0.002271689,0.00003449108],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625781,0.02036142,0.001494053,0.001469237,0.000479867,0.004402489,0.003179881,0.0002960117,0.005738975],"genre_scores_gemma":[0.974319,0.01165096,0.001982447,0.001838597,0.0004110843,0.003370265,0.002403014,0.00006082687,0.003963769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007748176,"threshold_uncertainty_score":0.02592027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02959360416677615,"score_gpt":0.3188886737373182,"score_spread":0.289295069570542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}