{"id":"W4229020741","doi":"10.1101/2022.05.06.490906","title":"Insulin Receptor Loss Impairs Mammary Tumorigenesis in Mice","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); University Health Network; Princess Margaret Cancer Centre; Statistics Canada; University of Toronto","funders":"Canadian Institutes of Health Research; Princess Margaret Hospital Foundation; Government of Canada; University Health Network","keywords":"Hyperinsulinemia; Insulin receptor; Carcinogenesis; Biology; Insulin; Cancer research; Cancer; Endocrinology; Phenotype; Mammary gland; Mammary tumor; Internal medicine; Breast cancer; Medicine; Insulin resistance; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005518287,0.001004839,0.000534842,0.001749651,0.0003763149,0.001063628,0.0007604503,0.001119997,0.005181735],"category_scores_gemma":[0.0002018442,0.000733756,0.0007506576,0.0006900569,0.0008128808,0.000462288,0.0006318372,0.002071528,0.00272448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007838861,"about_ca_system_score_gemma":0.0003832728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150904,"about_ca_topic_score_gemma":0.001223934,"domain_scores_codex":[0.9992219,0.0001152542,0.0000836897,0.0002260236,0.000198805,0.0001542883],"domain_scores_gemma":[0.9994994,0.00007435727,0.000179971,0.00009870364,0.00002452449,0.0001230833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005686447,0.0002135279,0.0002983034,0.00004991188,0.00002108168,0.0001574112,0.0000389807,0.0001842633,0.9954935,0.0007678467,0.0002675288,0.001938833],"study_design_scores_gemma":[0.0001597495,0.0007503425,0.003561018,0.00003988214,0.00005398503,0.0007856364,0.00007953188,0.001611827,0.9795735,0.0003870995,0.01297799,0.00001953415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595674,0.003480387,0.01224248,0.001183168,0.0002402979,0.000181904,0.009833477,0.001761547,0.01150924],"genre_scores_gemma":[0.9394884,0.003100506,0.008277694,0.000710955,0.00007915699,0.0003917914,0.006839914,0.0009578457,0.04015376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005181735,"threshold_uncertainty_score":0.01733464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008287522371227332,"score_gpt":0.2160873765331811,"score_spread":0.2077998541619537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}