{"id":"W4229021135","doi":"10.26508/lsa.202101358","title":"Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in <i>Candida albicans</i>","year":2022,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Genome Canada; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of General Medical Sciences; Canadian Institute for Advanced Research","keywords":"Shikimate pathway; Candida albicans; Aromatic amino acids; Biosynthesis; Biochemistry; Enzyme; Biology; Dehydratase; Corpus albicans; Amino acid; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005443182,0.0002104426,0.00009628715,0.0002661854,0.000135369,0.0002422035,0.0002101929,0.0001362421,0.0005148474],"category_scores_gemma":[0.00007602625,0.00008043986,0.000189482,0.0002046604,0.0001140704,0.00007349512,0.0001338409,0.0002703905,0.0002065829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002475589,"about_ca_system_score_gemma":0.0001346963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001809276,"about_ca_topic_score_gemma":0.00162249,"domain_scores_codex":[0.9999484,0.000005211834,0.000006637061,0.00001154251,0.00001519167,0.00001310259],"domain_scores_gemma":[0.9999281,0.00001096525,0.00001894516,0.000008382751,0.00001127143,0.00002230992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006264043,0.00001159396,0.0006263144,0.00001507959,0.000003146586,0.00008319785,0.00000940455,0.00005253441,0.9983011,0.00006735158,0.0000156996,0.0007520408],"study_design_scores_gemma":[0.00001014265,0.0001394207,0.03655455,0.00000672094,0.00002548928,0.0009643011,0.00007329429,0.001814991,0.9576333,0.00008234162,0.002686316,0.00000915903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978902,0.0004115051,0.0005923514,0.00003080183,0.000004891242,0.000006438817,0.000528968,0.0000183065,0.000516644],"genre_scores_gemma":[0.9963704,0.00030087,0.001195526,0.00002065615,0.000003696429,0.000005271019,0.001437889,0.0000111691,0.0006545744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001809276,"threshold_uncertainty_score":0.003597558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250689583145623,"score_gpt":0.2870386740021698,"score_spread":0.2745317781707136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}