{"id":"W4229021135","doi":"10.26508/lsa.202101358","title":"Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in <i>Candida albicans</i>","year":2022,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Genome Canada; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of General Medical Sciences; Canadian Institute for Advanced Research","keywords":"Shikimate pathway; Candida albicans; Aromatic amino acids; Biosynthesis; Biochemistry; Enzyme; Biology; Dehydratase; Corpus albicans; Amino acid; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007585565,0.0001218684,0.0002097163,0.0001352296,0.0001411069,0.00002845452,0.000572017,0.00004740008,0.00004551105],"category_scores_gemma":[0.0002278714,0.0001224084,0.00009882397,0.00163194,0.0006910834,0.00000840774,0.0006038422,0.0001330237,9.333128e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002202604,"about_ca_system_score_gemma":0.0001918908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002421944,"about_ca_topic_score_gemma":0.00006721727,"domain_scores_codex":[0.9981892,0.0001065577,0.0002401825,0.0006174322,0.0004707494,0.0003759543],"domain_scores_gemma":[0.9992204,0.00001279996,0.00008932517,0.0004375619,0.00006894486,0.0001709729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004446752,0.0001030258,0.01155998,0.00001648979,0.00004888284,0.000007030781,0.00002715262,0.0004199751,0.9872366,0.00007745009,0.00002366797,0.0004352855],"study_design_scores_gemma":[0.0003030867,0.00006794759,0.01126532,0.000005218184,0.00003301914,0.000002443278,0.00008054567,0.001563292,0.9853534,0.00003259873,0.001130484,0.0001626705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954823,0.001160143,0.002539911,0.0004373938,0.00003168139,0.0001459685,0.00004673334,0.000005216476,0.0001506439],"genre_scores_gemma":[0.9980442,0.0001677307,0.001175787,0.0004602035,0.00001059046,0.00003925615,0.00001882044,0.000008262688,0.00007517409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002561866,"threshold_uncertainty_score":0.4991668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250689583145623,"score_gpt":0.2870386740021698,"score_spread":0.2745317781707136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}