{"id":"W4229024039","doi":"10.1083/jcb.202105112","title":"V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy","year":2022,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Cancer Research UK","keywords":"Autophagy; ATG16L1; Cell biology; Regulator; Endocytosis; Lysosome; Biology; Chemistry; Phagocytosis; Biochemistry; Enzyme; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005359889,0.00009586601,0.0003783909,0.00009763392,0.0001001975,0.000001896965,0.0001742359,0.00006825916,0.0008421404],"category_scores_gemma":[0.00003027591,0.00006288206,0.0001378587,0.0001482217,0.0001881241,0.00002527259,0.00008744238,0.0003025445,0.000002131976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008372682,"about_ca_system_score_gemma":0.000311986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002620132,"about_ca_topic_score_gemma":8.603731e-7,"domain_scores_codex":[0.9990049,0.0002585243,0.0003356296,0.00008244446,0.0001575255,0.0001609576],"domain_scores_gemma":[0.9990229,0.0001849397,0.0004216418,0.0001641658,0.00009915579,0.0001072032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003754562,0.0006939501,0.002646021,0.00002928441,0.000672297,0.0001403872,0.001746272,0.00001981889,0.9863074,0.0002020508,0.002263421,0.001524558],"study_design_scores_gemma":[0.01570036,0.009826672,0.05327322,0.00005925895,0.001484446,0.0006783641,0.001814463,0.0006271555,0.901163,0.001914955,0.01319373,0.0002643381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962112,0.002142853,0.00002328555,0.0007488606,0.0001422181,0.0000998071,0.00002938089,0.000005634394,0.0005967412],"genre_scores_gemma":[0.997987,0.0004805866,0.00004618329,0.0009338786,0.00007203256,0.000001028774,0.00000382739,0.00001093805,0.0004645114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08514434,"threshold_uncertainty_score":0.9220847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008927924726136604,"score_gpt":0.2521453566827765,"score_spread":0.2432174319566399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}