{"id":"W4229026756","doi":"10.1101/2022.05.03.489748","title":"The role of dynamic DNA methylation in liver transplant rejection in children","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Differentially methylated regions; DNA methylation; Epigenetics; Methylation; Biology; Promoter; MHC class I; Gene; Major histocompatibility complex; Molecular biology; Cancer research; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002863142,0.0002532549,0.0002865815,0.0004488319,0.0002453334,0.0003746451,0.0002027589,0.0002870437,0.001388177],"category_scores_gemma":[0.0006783886,0.0001655841,0.0002447799,0.0004360034,0.0003088524,0.0002071283,0.0003486204,0.0003193217,0.0001629518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003167451,"about_ca_system_score_gemma":0.0002203058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002550596,"about_ca_topic_score_gemma":0.002591772,"domain_scores_codex":[0.9997522,0.00004353794,0.00001626221,0.00009351208,0.00004083444,0.00005365647],"domain_scores_gemma":[0.9996476,0.00007341606,0.0001989024,0.00001366022,0.00002218127,0.00004423358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006325294,0.00002011944,0.9453643,0.0001085595,0.00006615875,0.0003524513,0.0002660909,0.0003938191,0.03932441,0.0001296937,0.0001685943,0.01317327],"study_design_scores_gemma":[0.000005915045,0.0001513198,0.9920695,0.0000160469,0.00004235829,0.001358399,0.0002284275,0.0003561645,0.004958438,0.0001086292,0.0006989071,0.00000588999],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975682,0.001123169,0.0005268787,0.00004860293,0.000003102575,0.000004419883,0.0004590997,0.00001385368,0.0002527444],"genre_scores_gemma":[0.9985335,0.0004767037,0.0004480697,0.000024559,0.000005777653,0.00000692355,0.0003408852,0.000007223906,0.0001562975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002550596,"threshold_uncertainty_score":0.005071521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00504171830700926,"score_gpt":0.2089582865537778,"score_spread":0.2039165682467685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}