{"id":"W4229034592","doi":"10.25251/skin.6.supp.4","title":"Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 (TYK2) Inhibitor, in Moderate to Severe Plaque Psoriasis: 52-Week Efficacy Results From the Phase 3 POETYK PSO-1 and PSO-2 Trials","year":2022,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Bristol-Myers Squibb","keywords":"Plaque psoriasis; Medicine; Psoriasis; Internal medicine; Pharmacology; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001134721,0.0006360066,0.001575322,0.0001942956,0.0002893539,0.0007111335,0.0003507063,0.0005841177,0.002648554],"category_scores_gemma":[0.0004661895,0.0002174675,0.001029072,0.0001869055,0.0003423834,0.0005109568,0.0001687298,0.001710144,0.0006275869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004665398,"about_ca_system_score_gemma":0.0004535483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008880469,"about_ca_topic_score_gemma":0.003341989,"domain_scores_codex":[0.9997382,0.00008963106,0.00001775866,0.00004048377,0.000047818,0.00006618485],"domain_scores_gemma":[0.9996556,0.00008345292,0.00006864963,0.00002715214,0.00002891538,0.000136207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3770461,0.01372266,0.005181973,0.002221765,0.002401593,0.0002933722,0.0001819365,0.00280836,0.07549442,0.0003418987,0.01895005,0.5013559],"study_design_scores_gemma":[0.5100907,0.358111,0.07497375,0.0002954931,0.002479135,0.00177955,0.0001716958,0.004017463,0.02298894,0.0007276112,0.02422694,0.0001376811],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650593,0.02427244,0.0009354498,0.001011294,0.0002332666,0.0005817387,0.001556557,0.0002891305,0.00606081],"genre_scores_gemma":[0.9824321,0.009287119,0.000764743,0.000813823,0.0001648556,0.0002832977,0.002296216,0.00004459613,0.003913285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002648554,"threshold_uncertainty_score":0.00886035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04009431060346913,"score_gpt":0.302258072534325,"score_spread":0.2621637619308559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}