{"id":"W4229035783","doi":"10.1101/2022.05.06.490845","title":"Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Manitoba; Jewish General Hospital; McGill University; University of British Columbia","funders":"Fondation De Famille Alvin Segal; Jewish General Hospital; Canadian Institutes of Health Research; Genome Canada; McGill University; Warren Y. Soper Charitable Trust; Michael Smith Health Research BC; University of British Columbia; Vanderbilt University","keywords":"Hyperinsulinemia; Endocrinology; Pancreatic Intraepithelial Neoplasia; Internal medicine; Pancreatic cancer; Insulin; Pancreas; Hyperinsulinism; Biology; Cancer; Cancer research; KRAS; Medicine; Insulin resistance; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004030844,0.0003690471,0.0003437206,0.0004127159,0.0002170437,0.0007788768,0.0001452188,0.0003567531,0.004794883],"category_scores_gemma":[0.0001956939,0.0002122263,0.0004670098,0.0002968725,0.0003992133,0.0003716693,0.0003944859,0.00100351,0.00102161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003420186,"about_ca_system_score_gemma":0.0002495431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002536517,"about_ca_topic_score_gemma":0.0002359207,"domain_scores_codex":[0.9997292,0.00005989545,0.00002341829,0.0000714821,0.00007311279,0.00004288871],"domain_scores_gemma":[0.9998453,0.00002349479,0.00003869379,0.00003281711,0.00001722679,0.00004236324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004111586,0.00003943302,0.002048002,0.0001237298,0.0000261002,0.0003013792,0.00004123207,0.00008714182,0.9923317,0.0006617998,0.0003167899,0.003611432],"study_design_scores_gemma":[0.00007973898,0.0004151504,0.03429338,0.00003612747,0.00005588092,0.001977695,0.0002075504,0.001630548,0.9442368,0.001262942,0.01578695,0.00001740041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563992,0.01394276,0.01621128,0.00186452,0.0004579606,0.0001013151,0.001207544,0.0006231799,0.00919222],"genre_scores_gemma":[0.9799355,0.004623802,0.00634287,0.0003772186,0.0001324988,0.00005750094,0.0007560455,0.00007549884,0.007699119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004794883,"threshold_uncertainty_score":0.0160405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126052499504466,"score_gpt":0.2826419768267625,"score_spread":0.2613814518317178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}