{"id":"W4229040298","doi":"10.1021/acs.est.2c00973","title":"Health Risks of Chronic Exposure to Small Doses of Microcystins: An Integrative Metabolomic and Biochemical Study of Human Serum","year":2022,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Aquatic Ecosystems and Phytoplankton Dynamics","field":"Environmental Science","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"State Key Laboratory of Freshwater Ecology and Biotechnology; Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Metabolomics; Tolerable daily intake; Toxicity; Liquid chromatography–mass spectrometry; Physiology; Cyanobacteria; Human health; Tandem mass spectrometry; Metabolic pathway; Chemistry; Medicine; Environmental chemistry; Metabolism; Mass spectrometry; Pharmacology; Internal medicine; Biology; Chromatography; Body weight; Environmental health; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002220189,0.0003319216,0.0003644264,0.0003897916,0.000213406,0.000322685,0.0001003999,0.0002923944,0.000279642],"category_scores_gemma":[0.0001909686,0.0001149215,0.000261873,0.0004548088,0.0001975499,0.0001428581,0.0004164744,0.0002098381,0.0000796721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349711,"about_ca_system_score_gemma":0.0002500463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001369877,"about_ca_topic_score_gemma":0.001705339,"domain_scores_codex":[0.9998739,0.00002944924,0.000006647816,0.00004240876,0.00003336148,0.00001419886],"domain_scores_gemma":[0.99992,0.000008808349,0.00002321311,0.000007872873,0.00002624787,0.00001379532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002102904,0.0002041287,0.2009152,0.000277717,0.000354437,0.000367672,0.0004426547,0.0004391547,0.7659787,0.00008369288,0.0003494928,0.02848418],"study_design_scores_gemma":[0.00003943594,0.002271329,0.8985983,0.0000364165,0.0006037959,0.001440687,0.000550054,0.003254027,0.09009792,0.0002826218,0.002785939,0.00003959116],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995769,0.001815481,0.001468027,0.00006999644,0.000006624959,0.00002731687,0.0005325762,0.00002160429,0.0002892895],"genre_scores_gemma":[0.9955987,0.001315392,0.001759227,0.0001335973,0.0000157886,0.00003453112,0.0006947723,0.000005985481,0.000441984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369877,"threshold_uncertainty_score":0.002723813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491668491799085,"score_gpt":0.2763541911585003,"score_spread":0.2614375062405094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}