{"id":"W4229042560","doi":"10.3389/fnmol.2022.874299","title":"Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation","year":2022,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Fonds de Recherche du Québec - Santé; National Eye Institute; Multiple Sclerosis Society; Bloomberg Philanthropies; Maryland Stem Cell Research Fund; American Brain Foundation; New York Stem Cell Foundation; Research to Prevent Blindness; National Multiple Sclerosis Society","keywords":"Induced pluripotent stem cell; Precursor cell; Stem cell; Human Induced Pluripotent Stem Cells; Oligodendrocyte; Neuroscience; Cellular differentiation; Biology; Cell biology; Astrocyte; Cell; Embryonic stem cell; Myelin; Central nervous system; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002052052,0.0002688181,0.000293998,0.0002086707,0.00009083895,0.0002664215,0.0001136078,0.000173414,0.001152077],"category_scores_gemma":[0.0002191752,0.0001068775,0.0002744633,0.0002351825,0.0001524355,0.00007915616,0.0002032184,0.0004078988,0.0004178936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007147815,"about_ca_system_score_gemma":0.0001513089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003720866,"about_ca_topic_score_gemma":0.0006134312,"domain_scores_codex":[0.9997107,0.00003862352,0.00004593822,0.00004449331,0.0001156815,0.00004452252],"domain_scores_gemma":[0.9998519,0.00004349664,0.00003369825,0.00002413446,0.00003025339,0.00001645398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005246004,0.00001344592,0.0001851296,0.00003541445,0.000005437662,0.0000509358,0.00002837623,0.00005103821,0.9982588,0.00005312694,0.00004609199,0.001219802],"study_design_scores_gemma":[0.00001275029,0.0003774249,0.003887775,0.000009421145,0.00002845914,0.0002577999,0.00003652783,0.0006509558,0.9896096,0.0000633927,0.005061908,0.000004047743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824029,0.002423912,0.009943827,0.0001107673,0.00008899849,0.0001624561,0.001658364,0.0001957579,0.003012914],"genre_scores_gemma":[0.9840419,0.001936505,0.006319749,0.0001971159,0.00003320886,0.0001522344,0.004009457,0.00006078611,0.003249003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152077,"threshold_uncertainty_score":0.003854036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069060821327206,"score_gpt":0.2266325021079016,"score_spread":0.2059418938946296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}