{"id":"W4229046619","doi":"10.1093/ndt/gfac067.011","title":"MO212: Updated Interim Results of A Phase 1/2 Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Activity of BION-1301 in Patients With IGA Nephropathy","year":2022,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Chinook Regional Hospital","funders":"","keywords":"Medicine; Pathogenesis; Pharmacokinetics; Tolerability; Immunology; Nephropathy; Adverse effect; Pharmacodynamics; Proteinuria; Antibody; Immunoglobulin A; Glomerulonephritis; Immune system; Internal medicine; Pharmacology; Kidney; Immunoglobulin G; Endocrinology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00596084,0.001401799,0.003090916,0.0004553207,0.0005751528,0.001817118,0.0009895146,0.001765606,0.005167932],"category_scores_gemma":[0.003222302,0.0005128048,0.002227528,0.0006144959,0.0006169845,0.001114241,0.0005112033,0.0033037,0.001461886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001117039,"about_ca_system_score_gemma":0.001993753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000967856,"about_ca_topic_score_gemma":0.002651252,"domain_scores_codex":[0.9981002,0.001002047,0.000121833,0.0002296279,0.0003023227,0.0002439007],"domain_scores_gemma":[0.9974975,0.0005070758,0.0005754341,0.0002510168,0.0003964239,0.0007724733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4360788,0.01902215,0.02663294,0.004463225,0.01001143,0.00105161,0.0003151484,0.004706006,0.06523146,0.001075186,0.04322875,0.3881833],"study_design_scores_gemma":[0.2925928,0.4952162,0.08913472,0.000659748,0.007449269,0.002597419,0.0001125645,0.002902991,0.01146997,0.001424102,0.09621483,0.0002255727],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8672214,0.04955576,0.009542063,0.007871774,0.001581892,0.009051173,0.03381357,0.001332814,0.02002957],"genre_scores_gemma":[0.9082484,0.01319656,0.01208673,0.01164359,0.001046166,0.007175043,0.03631954,0.0003009652,0.009983082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00596084,"threshold_uncertainty_score":0.0315243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01687348162952206,"score_gpt":0.3254512351731908,"score_spread":0.3085777535436687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}