{"id":"W4229050512","doi":"10.1007/s13346-022-01171-0","title":"Statistical optimization of voriconazole nanoparticles loaded carboxymethyl chitosan-poloxamer based in situ gel for ocular delivery: In vitro, ex vivo, and toxicity assessment","year":2022,"lang":"en","type":"article","venue":"Drug Delivery and Translational Research","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Science and Engineering Research Board","keywords":"Ex vivo; Voriconazole; Chitosan; In vivo; Toxicity; In vitro; Poloxamer; Chemistry; Pharmacology; Medicine; Biochemistry; Antifungal; Biology; Biotechnology; Dermatology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002939193,0.0002297051,0.0001967079,0.0002658597,0.0001313386,0.0002334499,0.0001509248,0.0001740061,0.0008747668],"category_scores_gemma":[0.0003942803,0.0001157806,0.0002658856,0.0002296485,0.0001567275,0.0001346068,0.00009153501,0.0001785605,0.0001521524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003301977,"about_ca_system_score_gemma":0.00022723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001942337,"about_ca_topic_score_gemma":0.003643557,"domain_scores_codex":[0.9998327,0.00001684725,0.0000155485,0.00003678115,0.00007732365,0.00002074405],"domain_scores_gemma":[0.9997787,0.00006222584,0.00006834204,0.000009937076,0.00007172369,0.000009149768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001142001,0.00002793476,0.0003974499,0.00007211038,0.00000715951,0.00003114303,0.00001545315,0.001434477,0.9934185,0.0000620741,0.00004826983,0.004371376],"study_design_scores_gemma":[0.000004794863,0.0003010819,0.003188424,0.000002649672,0.0000277805,0.0000444156,0.00001764309,0.008869843,0.9869796,0.00002089381,0.0005355761,0.000007363922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983949,0.0009271007,0.01336362,0.00006174506,0.00002726054,0.00004319738,0.0002372924,0.0001078548,0.001282974],"genre_scores_gemma":[0.9878648,0.00061395,0.009244734,0.00002244721,0.000007688006,0.0000485084,0.0002036801,0.00003380778,0.0019604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001942337,"threshold_uncertainty_score":0.003862083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1057143918146185,"score_gpt":0.443958127669496,"score_spread":0.3382437358548774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}