{"id":"W4229050670","doi":"10.1093/ndt/gfac070.013","title":"MO399: Remodel: A Mechanistic Trial Evaluating the Effects of Semaglutide on the Kidneys In People With Type 2 Diabetes and Chronic Kidney Disease","year":2022,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Semaglutide; Medicine; Kidney disease; Internal medicine; Clinical trial; Type 2 diabetes; Kidney; Diabetes mellitus; Intensive care medicine; Endocrinology; Liraglutide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001280102,0.0007618938,0.001406841,0.0002563704,0.0004018737,0.0009001704,0.00044533,0.001485082,0.007053565],"category_scores_gemma":[0.001004985,0.0002363318,0.001760356,0.000238576,0.0004135742,0.0007254363,0.0005448805,0.002296906,0.0005885453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004418727,"about_ca_system_score_gemma":0.0007880263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006096523,"about_ca_topic_score_gemma":0.001398656,"domain_scores_codex":[0.9996231,0.0001752252,0.00002564792,0.0000755455,0.00003456519,0.00006592514],"domain_scores_gemma":[0.9994567,0.0001059838,0.0001133682,0.00003282802,0.0000473365,0.0002437677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.862738,0.01197067,0.005588681,0.003143889,0.00463921,0.0002247362,0.0001118026,0.0007081527,0.009571032,0.0009852235,0.005684136,0.09463451],"study_design_scores_gemma":[0.8056031,0.1565356,0.02035338,0.0006371947,0.00349287,0.0003200129,0.000124546,0.001244023,0.002003985,0.001321107,0.008299506,0.00006469314],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649734,0.02017217,0.0006744908,0.002603119,0.0005337918,0.001413249,0.002613855,0.0001867168,0.006829246],"genre_scores_gemma":[0.9822697,0.004602409,0.001888733,0.003966174,0.0004728603,0.001638708,0.001777655,0.00002777494,0.003355929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007053565,"threshold_uncertainty_score":0.02359647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033407141815173,"score_gpt":0.2529341021471317,"score_spread":0.24260003072898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}