{"id":"W4229053081","doi":"10.1007/s13346-022-01147-0","title":"Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials","year":2022,"lang":"en","type":"review","venue":"Drug Delivery and Translational Research","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"H2020 Leadership in Enabling and Industrial Technologies","keywords":"Toxicity; In vivo; Liver toxicity; In vitro; Clinical trial; Translation (biology); Human liver; Bridging (networking); Animal testing; Medicine; Pharmacology; Bioinformatics; Biology; Pathology; Computer science; Biotechnology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003747861,0.0008862292,0.001207613,0.00182474,0.000425612,0.002262487,0.001045143,0.00168061,0.002196212],"category_scores_gemma":[0.001911327,0.0005583628,0.001259353,0.0009051714,0.00117858,0.001413028,0.00142927,0.002922067,0.001335058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008264919,"about_ca_system_score_gemma":0.001119381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001430104,"about_ca_topic_score_gemma":0.003169974,"domain_scores_codex":[0.9981074,0.0007209918,0.0001374736,0.000182223,0.0007687701,0.00008310471],"domain_scores_gemma":[0.9980782,0.0008279828,0.0003029955,0.00033211,0.0003219068,0.0001366487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007934375,0.0004852263,0.002721705,0.006197195,0.000304289,0.001120019,0.0004684171,0.007297054,0.7965944,0.01904233,0.01473743,0.1502386],"study_design_scores_gemma":[0.0001543688,0.002532277,0.006054358,0.001465637,0.0006904506,0.003791039,0.0005114317,0.01305125,0.5791218,0.01243011,0.379957,0.0002404244],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.0827778,0.2541808,0.6013203,0.008372336,0.003084806,0.001391103,0.006036242,0.003389144,0.03944761],"genre_scores_gemma":[0.3915594,0.2355443,0.3438796,0.004374313,0.0006018996,0.00351675,0.005969431,0.0007441369,0.01381024],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003747861,"threshold_uncertainty_score":0.01982087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5967766714342599,"score_gpt":0.5043170574833435,"score_spread":0.0924596139509164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}