{"id":"W4229054255","doi":"10.1182/bloodadvances.2022007340","title":"Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance","year":2022,"lang":"en","type":"article","venue":"Blood Advances","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Science Foundation Ireland; Health Research Board; Health Service Executive; Wellcome Trust; Canadian Institute for Theoretical Astrophysics","keywords":"Desmopressin; Von Willebrand factor; Von Willebrand disease; Pathogenesis; Internal medicine; Medicine; Endocrinology; Gastroenterology; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580046,0.0001137451,0.0003307353,0.00004264171,0.000178319,0.000006623344,0.0001118864,0.00003444503,0.00001317282],"category_scores_gemma":[0.0001910843,0.00009120387,0.00008678259,0.0003045973,0.0001484806,0.00009616222,0.00005780021,0.0001713837,0.000002602107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001121588,"about_ca_system_score_gemma":0.0001733806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001703127,"about_ca_topic_score_gemma":0.0004210906,"domain_scores_codex":[0.9988035,0.0001173715,0.0003833188,0.00029159,0.0002278361,0.0001763777],"domain_scores_gemma":[0.9992466,0.0002497517,0.0001728655,0.0002397219,0.00004023798,0.00005082732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003826167,0.01791173,0.6245371,0.0007726635,0.00112662,0.000768964,0.004161869,0.004911989,0.06213855,0.01412952,0.0002523965,0.2654625],"study_design_scores_gemma":[0.01258118,0.001890651,0.9484072,0.0003400849,0.0005018132,0.00006219331,0.002980907,0.0004192766,0.01994993,0.001762926,0.01067622,0.0004276246],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918697,0.00496045,0.00005105415,0.0006520164,0.000194566,0.0005347296,0.0000416044,0.00002405183,0.001671767],"genre_scores_gemma":[0.9958296,0.003064085,0.0004172951,0.0003481924,0.00003099707,0.0001365884,0.0000106624,0.0000136971,0.0001488922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3238701,"threshold_uncertainty_score":0.3719186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02808968300811859,"score_gpt":0.2949380253344919,"score_spread":0.2668483423263733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}