{"id":"W4229056645","doi":"10.1021/acs.jnatprod.1c01225","title":"Ansellone J, a Potent <i>in Vitro</i> and <i>ex Vivo</i> HIV-1 Latency Reversal Agent Isolated from a <i>Phorbas</i> sp. Marine Sponge","year":2022,"lang":"en","type":"review","venue":"Journal of Natural Products","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Wellcome; Philadelphia Foundation; Canadian Institutes of Health Research; New Partnership for Africa's Development; Simon Fraser University; Government of the United Kingdom; Natural Sciences and Engineering Research Council of Canada; African Academy of Sciences; Government of Canada; Wistar Institute; Wellcome Trust","keywords":"Ex vivo; Sponge; Latency (audio); In vitro; In vivo; Context (archaeology); Chemistry; Stereochemistry; Human immunodeficiency virus (HIV); Activator (genetics); Biology; Biochemistry; Virology; Genetics; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0008521391,0.0008754163,0.003364396,0.0007639806,0.0001100159,0.00005954027,0.0003443281,0.0002844527,0.0003240047],"category_scores_gemma":[0.0002668097,0.000613654,0.0006322169,0.001131259,0.00007635185,0.0002418759,0.0003406046,0.002402839,0.00005136444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008749191,"about_ca_system_score_gemma":0.000921682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004773621,"about_ca_topic_score_gemma":0.000007115274,"domain_scores_codex":[0.995325,0.00035292,0.001894375,0.0008250988,0.000997089,0.0006055069],"domain_scores_gemma":[0.9973288,0.0002057249,0.001384181,0.0005193698,0.0002304191,0.0003315243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003405462,0.001722849,0.0002018154,0.008878935,0.003424739,0.02363245,0.0007521023,7.431328e-7,0.001375444,0.00000448613,0.0580212,0.8985798],"study_design_scores_gemma":[0.00324664,0.0003077562,0.00007393226,0.005120988,0.003175007,0.004348296,0.00004144096,0.00000913687,0.0002356324,0.00002385474,0.9828529,0.0005644456],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003659762,0.989242,8.812134e-7,0.003700614,0.00143629,0.001484053,0.0001238792,0.00003412143,0.0003184417],"genre_scores_gemma":[0.0005684745,0.9817134,0.002423702,0.0003297045,0.0007859397,0.00002117868,0.0006351574,0.0001133755,0.01340911],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9248317,"threshold_uncertainty_score":0.9998987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223496899438943,"score_gpt":0.2643598604073769,"score_spread":0.2420101704634826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}