{"id":"W4229056645","doi":"10.1021/acs.jnatprod.1c01225","title":"Ansellone J, a Potent <i>in Vitro</i> and <i>ex Vivo</i> HIV-1 Latency Reversal Agent Isolated from a <i>Phorbas</i> sp. Marine Sponge","year":2022,"lang":"en","type":"review","venue":"Journal of Natural Products","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Wellcome; Philadelphia Foundation; Canadian Institutes of Health Research; New Partnership for Africa's Development; Simon Fraser University; Government of the United Kingdom; Natural Sciences and Engineering Research Council of Canada; African Academy of Sciences; Government of Canada; Wistar Institute; Wellcome Trust","keywords":"Ex vivo; Sponge; Latency (audio); In vitro; In vivo; Context (archaeology); Chemistry; Stereochemistry; Human immunodeficiency virus (HIV); Activator (genetics); Biology; Biochemistry; Virology; Genetics; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557735,0.0005761374,0.0004708401,0.001216413,0.0001608018,0.0004037133,0.000272961,0.0004002074,0.002737484],"category_scores_gemma":[0.0001269775,0.0001723489,0.0002571204,0.0008394367,0.0002488028,0.0005479765,0.000260878,0.0008535787,0.001132984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003193046,"about_ca_system_score_gemma":0.0004599243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001219192,"about_ca_topic_score_gemma":0.002580119,"domain_scores_codex":[0.9999584,0.000004047954,0.000004341496,0.000009927589,0.00001526164,0.000008119247],"domain_scores_gemma":[0.9999495,0.00001248031,0.00001265021,0.00000196523,0.00001269168,0.00001085906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002305983,0.000217118,0.0002854921,0.01247574,0.00009719578,0.0002744799,0.00007282919,0.000708489,0.0409216,0.002957703,0.01030522,0.9314535],"study_design_scores_gemma":[0.00007865787,0.0006672854,0.002528822,0.001340328,0.0001884665,0.001699925,0.00008887988,0.0001880181,0.02175822,0.0009682851,0.9704592,0.00003402186],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003324312,0.9895008,0.0005771032,0.0002133837,0.0001656334,0.0000344364,0.0001322162,0.0000354078,0.006016711],"genre_scores_gemma":[0.01508552,0.9781086,0.0009323057,0.000415816,0.00008734491,0.0000326208,0.0002309807,0.000005689789,0.005101073],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002737484,"threshold_uncertainty_score":0.009157836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223496899438943,"score_gpt":0.2643598604073769,"score_spread":0.2420101704634826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}