{"id":"W4229057468","doi":"10.1016/j.jcf.2022.04.019","title":"Caution advised in the use of CFTR modulator treatment for individuals harboring specific CFTR variants","year":2022,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Institute for Clinical Evaluative Sciences; SickKids Foundation; Hospital for Sick Children","funders":"Cystic Fibrosis Foundation","keywords":"Medicine; Frameshift mutation; Cystic fibrosis; Ivacaftor; Nonsense; Food and drug administration; Drug; Cystic fibrosis transmembrane conductance regulator; Bioinformatics; Pharmacology; Genetics; Mutation; Gene; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0097834,0.0008142072,0.003143994,0.001583552,0.002338415,0.003007076,0.002422651,0.01661798,0.006575001],"category_scores_gemma":[0.05587896,0.0006947255,0.001886702,0.0007563035,0.002827299,0.002415042,0.0009798444,0.01538004,0.005064852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007265758,"about_ca_system_score_gemma":0.002444453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006224353,"about_ca_topic_score_gemma":0.01500613,"domain_scores_codex":[0.9911561,0.004039152,0.001719935,0.000815865,0.001905035,0.0003639483],"domain_scores_gemma":[0.9650362,0.02443766,0.002419933,0.001638178,0.004494353,0.001973779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002655976,0.0007742412,0.03184605,0.002940798,0.0006939559,0.04615202,0.007833636,0.0008746319,0.01148437,0.008230618,0.6681788,0.218335],"study_design_scores_gemma":[0.001085792,0.0009121895,0.03160627,0.01411725,0.0007172945,0.07119042,0.007172918,0.002587446,0.009371063,0.02671542,0.8340216,0.0005023709],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0513502,0.05498825,0.0278252,0.7737356,0.02773426,0.0007925189,0.001002884,0.002068682,0.06050249],"genre_scores_gemma":[0.2111683,0.02463059,0.07923658,0.6249788,0.0223785,0.001113662,0.000419591,0.0006677949,0.03540619],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01661798,"threshold_uncertainty_score":0.05174017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0703584061918905,"score_gpt":0.3247417393579983,"score_spread":0.2543833331661078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}