{"id":"W4229060959","doi":"10.1111/hae.14530","title":"Gene therapy – are we ready now?","year":2022,"lang":"en","type":"article","venue":"Haemophilia","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Genetic enhancement; Medicine; Haemophilia; Factor IX; Adeno-associated virus; Haemophilia A; Immune system; Transgene; Bioinformatics; Gene; Vector (molecular biology); Intensive care medicine; Immunology; Genetics; Biology; Pediatrics; Internal medicine; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005037793,0.0008117,0.001312788,0.0008076082,0.0008758343,0.0048149,0.00143587,0.006726152,0.04120766],"category_scores_gemma":[0.008988533,0.0003069613,0.0007237725,0.0006118664,0.004401742,0.008564629,0.001475573,0.01089507,0.02147475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001897423,"about_ca_system_score_gemma":0.002582091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001146195,"about_ca_topic_score_gemma":0.001613649,"domain_scores_codex":[0.9978122,0.000602179,0.000126297,0.0003066769,0.000918399,0.0002342901],"domain_scores_gemma":[0.9935508,0.002292179,0.000516601,0.0003134482,0.002157908,0.001169013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001468278,0.0001056557,0.0004167098,0.001492311,0.00002911551,0.0002747204,0.0002043171,0.0002549247,0.002167864,0.0321364,0.651016,0.3117552],"study_design_scores_gemma":[0.0000202493,0.0001210875,0.0001816123,0.001066165,0.00001229081,0.000461599,0.0002095261,0.00009397237,0.0003835744,0.01521166,0.9822128,0.00002546984],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0008611388,0.3102592,0.004039282,0.6272532,0.03590772,0.00006143318,0.0002313391,0.0004416862,0.02094501],"genre_scores_gemma":[0.01298441,0.5436513,0.006567371,0.3387891,0.03926358,0.0001576839,0.0006637409,0.000308761,0.05761404],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04120766,"threshold_uncertainty_score":0.1378534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04321706537555714,"score_gpt":0.3120832957678495,"score_spread":0.2688662303922924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}