{"id":"W4229067787","doi":"10.1002/hep.32562","title":"Endoplasmic reticulum stress in liver diseases","year":2022,"lang":"en","type":"review","venue":"Hepatology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":388,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; National Institute of Diabetes and Digestive and Kidney Diseases; Labex Immuno-Oncology; National Key Research and Development Program of China; Cancéropôle Ile de France; Ligue Contre le Cancer; National Heart, Lung, and Blood Institute; Institut Universitaire de France; Fudan University; Fondation pour la Recherche Médicale; National Natural Science Foundation of China; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Association pour la Recherche sur le Cancer; European Commission; Institut Gustave-Roussy; Fondation Leducq; Agence Nationale de la Recherche; Centre National de la Recherche Scientifique; Equipex","keywords":"Unfolded protein response; Endoplasmic reticulum; Homeostasis; Cell biology; Biology; ATF6; Medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004262128,0.0009525143,0.001106903,0.001744632,0.0003296998,0.0008487396,0.0007233915,0.001121461,0.006360945],"category_scores_gemma":[0.0005525858,0.0001851292,0.0003918038,0.001912829,0.0004280866,0.001005029,0.0009084061,0.001856352,0.00553851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005784403,"about_ca_system_score_gemma":0.0009177611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007435753,"about_ca_topic_score_gemma":0.001127095,"domain_scores_codex":[0.9998173,0.00003566933,0.00002794889,0.00002903868,0.00006968123,0.00002039633],"domain_scores_gemma":[0.999796,0.00006770262,0.00002636588,0.000009654926,0.00007234803,0.00002794662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007129412,0.00004763323,0.0001305893,0.01100385,0.00006734482,0.0002340477,0.00006078889,0.0002329956,0.001233779,0.00426295,0.08670999,0.8959445],"study_design_scores_gemma":[0.000008497299,0.00004443164,0.0004614699,0.002000098,0.00004059576,0.001101582,0.00002624356,0.00003620509,0.0001936701,0.001642285,0.9944347,0.00001025382],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007154483,0.9970487,0.0001664151,0.0003387352,0.0006302039,0.000005501456,0.00002368351,0.000018057,0.001697248],"genre_scores_gemma":[0.0006561457,0.9967901,0.0001959163,0.0003343351,0.0004715861,0.000006719434,0.0000525054,0.000003192555,0.001489394],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006360945,"threshold_uncertainty_score":0.02127951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02628773109766427,"score_gpt":0.2954895798704404,"score_spread":0.2692018487727761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}