{"id":"W4229080238","doi":"10.3389/fviro.2022.849936","title":"Alpha, Beta, Delta, Omicron, and SARS-CoV-2 Breakthrough Cases: Defining Immunological Mechanisms for Vaccine Waning and Vaccine-Variant Mismatch","year":2022,"lang":"en","type":"article","venue":"Frontiers in Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Research Nova Scotia; Canadian Institutes of Health Research; Dalhousie University; Genome Canada; Dalhousie Medical Research Foundation","keywords":"Vaccination; Virology; Immune system; Immunization; Population; Immunology; Biology; Pandemic; Antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Antigen; Vaccine efficacy; Coronavirus disease 2019 (COVID-19); Disease; Medicine; Infectious disease (medical specialty); Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002243443,0.000430804,0.0006510197,0.0008704434,0.0003588784,0.001463986,0.0006262655,0.0008548741,0.001248516],"category_scores_gemma":[0.002895214,0.0002524786,0.0002613158,0.0004579218,0.001035141,0.001598582,0.0007416366,0.0007165673,0.000253687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007980593,"about_ca_system_score_gemma":0.0005160617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000662508,"about_ca_topic_score_gemma":0.0006053287,"domain_scores_codex":[0.999151,0.0002851263,0.00005854768,0.0001347883,0.000138707,0.0002317665],"domain_scores_gemma":[0.9987691,0.0003251026,0.0005618215,0.00007987568,0.0001420162,0.0001219564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003716271,0.0005956064,0.7112237,0.001015624,0.0001972031,0.003075922,0.001640816,0.001400047,0.05235419,0.01374052,0.003079688,0.2079604],"study_design_scores_gemma":[0.0001606113,0.003556259,0.9187887,0.0006096796,0.0002641304,0.01452185,0.004035303,0.005595463,0.01533088,0.01499705,0.02204963,0.00009039481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9240183,0.06309355,0.00266281,0.002121691,0.00009838392,0.0001104955,0.0001684928,0.00004605835,0.007680247],"genre_scores_gemma":[0.9914928,0.006631077,0.0007911694,0.0003588957,0.0001543829,0.00004027275,0.0001034125,0.000006977815,0.0004210682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002243443,"threshold_uncertainty_score":0.0118646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02513825940637677,"score_gpt":0.3066529533827849,"score_spread":0.2815146939764081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}