{"id":"W4229080238","doi":"10.3389/fviro.2022.849936","title":"Alpha, Beta, Delta, Omicron, and SARS-CoV-2 Breakthrough Cases: Defining Immunological Mechanisms for Vaccine Waning and Vaccine-Variant Mismatch","year":2022,"lang":"en","type":"article","venue":"Frontiers in Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Research Nova Scotia; Canadian Institutes of Health Research; Dalhousie University; Genome Canada; Dalhousie Medical Research Foundation","keywords":"Vaccination; Virology; Immune system; Immunization; Population; Immunology; Biology; Pandemic; Antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Antigen; Vaccine efficacy; Coronavirus disease 2019 (COVID-19); Disease; Medicine; Infectious disease (medical specialty); Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009638474,0.000339335,0.0009315823,0.0004213937,0.0004001877,0.00003511244,0.0002639751,0.0002546528,0.00002097045],"category_scores_gemma":[0.0002452633,0.0003246478,0.0001067274,0.0003045731,0.0001073496,0.0001090009,0.0005420209,0.0007752053,0.00000402705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002281438,"about_ca_system_score_gemma":0.0001568217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006749713,"about_ca_topic_score_gemma":0.0001460415,"domain_scores_codex":[0.9972613,0.0002499425,0.0005617961,0.0008451062,0.0002317759,0.0008501195],"domain_scores_gemma":[0.9990108,0.0003479702,0.0001411985,0.0003878778,0.00006364289,0.00004852684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01773489,0.0008915712,0.1432361,0.0004507778,0.001040821,0.00500659,0.003775715,0.00001036331,0.741232,0.007562275,0.02919665,0.04986231],"study_design_scores_gemma":[0.06349386,0.02015305,0.04826876,0.0002099282,0.001329856,0.02522363,0.01514631,0.02668177,0.2343064,0.05613768,0.5061911,0.002857668],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627369,0.01053499,0.02250862,0.002393647,0.0006058668,0.0009457906,0.00007010039,0.00007745028,0.0001266378],"genre_scores_gemma":[0.9354717,0.0001416332,0.02911792,0.03449591,0.00009483677,0.0005118623,0.00005590716,0.0000820619,0.0000282068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5069256,"threshold_uncertainty_score":0.9999205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02513825940637677,"score_gpt":0.3066529533827849,"score_spread":0.2815146939764081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}