{"id":"W4229083083","doi":"10.1093/ndt/gfac067.006","title":"MO207: A Phase 1/2, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BION-1301 in Healthy Volunteers and Adults with IGA Nephropathy","year":2022,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Chinook Regional Hospital","funders":"","keywords":"Medicine; Tolerability; Pathogenesis; Immunology; Immunogenicity; Nephropathy; Kidney disease; Glomerulonephritis; Proteinuria; Pharmacodynamics; Internal medicine; Pharmacokinetics; Immune system; Placebo; Gastroenterology; Kidney; Endocrinology; Adverse effect; Pathology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002218961,0.00171448,0.001909669,0.0004451484,0.0006078688,0.0007930354,0.0007272831,0.001374566,0.003230826],"category_scores_gemma":[0.0009615696,0.0005820756,0.0009953651,0.0003586368,0.00112645,0.0007269377,0.0004835733,0.002462041,0.0008915153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007519897,"about_ca_system_score_gemma":0.001832584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006900813,"about_ca_topic_score_gemma":0.001244624,"domain_scores_codex":[0.9990667,0.0004961973,0.00002826283,0.0001536711,0.00009225783,0.0001629707],"domain_scores_gemma":[0.9991789,0.00008606939,0.0001353198,0.00006043029,0.00006546939,0.0004737606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6804045,0.1533335,0.0156817,0.000862092,0.001191265,0.0004073893,0.0003370352,0.001394409,0.07185163,0.0002959435,0.003778662,0.07046191],"study_design_scores_gemma":[0.209114,0.7662065,0.01792958,0.00002419894,0.0003345047,0.0003263317,0.00006792337,0.0007731214,0.002530762,0.0001247768,0.002532238,0.00003607552],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914926,0.001189879,0.0009204505,0.0003066985,0.0001147196,0.004063475,0.0009516044,0.0001096912,0.0008508381],"genre_scores_gemma":[0.9846522,0.001057113,0.002822869,0.00154399,0.0003095541,0.005399296,0.001820215,0.00004244663,0.002352392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003230826,"threshold_uncertainty_score":0.01173514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009111620264765894,"score_gpt":0.2850662229951778,"score_spread":0.2759546027304119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}