{"id":"W4229369340","doi":"10.1128/msphere.00075-22","title":"High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11","year":2022,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; National Institute of Allergy and Infectious Diseases; Japan Agency for Medical Research and Development","keywords":"Candida albicans; Throughput; Chemistry; Pharmacology; Microbiology; Medicine; Computer science; Biology; Telecommunications","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267872,0.0004096805,0.0002897721,0.0003735461,0.0002325278,0.0002354746,0.0003585886,0.000259996,0.002131638],"category_scores_gemma":[0.0001213379,0.0001050402,0.0002275635,0.0003073434,0.0001230721,0.000147199,0.0001727559,0.0003090815,0.0004827384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002548941,"about_ca_system_score_gemma":0.0003563416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001526153,"about_ca_topic_score_gemma":0.005364224,"domain_scores_codex":[0.9998826,0.0000132656,0.000005088132,0.00001810492,0.00006228646,0.00001857948],"domain_scores_gemma":[0.999953,0.000009577193,0.000009037004,0.000005257502,0.00001177964,0.00001127096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000188415,0.0002815656,0.0006376468,0.0001578557,0.00003252384,0.0002725927,0.00001291931,0.0006620292,0.9834071,0.0002254154,0.0003826995,0.01373935],"study_design_scores_gemma":[0.00005817585,0.001836311,0.004824763,0.00001805125,0.00009184628,0.0007700645,0.00003717804,0.002329368,0.9818287,0.0000856509,0.008102929,0.00001696816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714523,0.007374946,0.007250389,0.0003018445,0.00008431964,0.0002404216,0.002462587,0.0004032106,0.01042993],"genre_scores_gemma":[0.9832335,0.003943449,0.004515217,0.0001090769,0.00001078271,0.00003548445,0.002049564,0.00001943343,0.006083626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002131638,"threshold_uncertainty_score":0.00713104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332017244362481,"score_gpt":0.2734527948893917,"score_spread":0.2601326224457669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}