{"id":"W4229369340","doi":"10.1128/msphere.00075-22","title":"High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11","year":2022,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; National Institute of Allergy and Infectious Diseases; Japan Agency for Medical Research and Development","keywords":"Candida albicans; Throughput; Chemistry; Pharmacology; Microbiology; Medicine; Computer science; Biology; Telecommunications","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002302596,0.0001796819,0.0004706943,0.00002799212,0.0001613342,0.00001466358,0.000193588,0.00008048822,0.006906835],"category_scores_gemma":[0.0001431864,0.0001667723,0.0001446053,0.0003489415,0.0002283452,0.0001315027,0.0001491842,0.0003269115,0.00003215858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001619771,"about_ca_system_score_gemma":0.0002881171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004096336,"about_ca_topic_score_gemma":0.001440776,"domain_scores_codex":[0.9982347,0.00005098213,0.0003943326,0.0004331348,0.0005912724,0.0002955546],"domain_scores_gemma":[0.9989612,0.00004378816,0.0001138476,0.0005731013,0.0001235872,0.0001845457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005665107,0.002328038,0.1417514,0.0005826208,0.0004152645,0.0005893488,0.002153876,0.0001139534,0.7958876,0.004739657,0.03822324,0.007549868],"study_design_scores_gemma":[0.01319045,0.004326734,0.290063,0.00061868,0.001004319,0.0002543621,0.01811679,0.0007722954,0.6203575,0.00441974,0.04515088,0.001725325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962041,0.0004892905,0.00004111751,0.0005297406,0.0002136479,0.0003185519,0.0001333101,0.00008505055,0.001985127],"genre_scores_gemma":[0.9957367,0.00002244545,0.0003873152,0.0002672978,0.0002150045,0.00003429544,0.0002208422,0.000028601,0.003087495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1755302,"threshold_uncertainty_score":0.994001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332017244362481,"score_gpt":0.2734527948893917,"score_spread":0.2601326224457669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}