{"id":"W4229371045","doi":"10.3390/molecules27093019","title":"Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Associazione Italiana per la Ricerca sul Cancro; Fondazione Italiana per la Ricerca sul Cancro; Canadian Institutes of Health Research; Ministero dell’Istruzione, dell’Università e della Ricerca; Università di Pisa; GlaxoSmithKline","keywords":"Chemistry; Neuroblastoma; In vitro; Cancer cell; Cannabinoid receptor; Cannabinoid; Cannabinoid receptor type 2; Cell culture; Viability assay; Pharmacology; Cancer; Cancer research; Receptor; Biochemistry; Biology; Agonist; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002002163,0.0004021562,0.0004041633,0.0001516301,0.00017742,0.0001230253,0.0002342443,0.0001539285,0.001257264],"category_scores_gemma":[0.0001106343,0.00009252025,0.0002151664,0.0001929076,0.00008900002,0.0001210241,0.0001139483,0.0002889027,0.0004792228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000320609,"about_ca_system_score_gemma":0.000314405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002221201,"about_ca_topic_score_gemma":0.004730342,"domain_scores_codex":[0.9999126,0.000015714,0.000009654321,0.00001570444,0.00003029709,0.00001597835],"domain_scores_gemma":[0.9999549,0.000007534946,0.000009538982,0.000005439987,0.00001252395,0.00001006077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006034634,0.00002620087,0.00003846694,0.00006789037,0.000003088873,0.0000352948,0.0000151807,0.0001215999,0.9982477,0.00003163093,0.00002909058,0.001323515],"study_design_scores_gemma":[0.00001839317,0.0004677483,0.001022163,0.000006813155,0.00002080998,0.0001345133,0.00001466429,0.0002071151,0.9946973,0.00001460486,0.003391193,0.000004690591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972654,0.01205117,0.007552991,0.0001174368,0.00004374246,0.000264575,0.002514001,0.00008344237,0.004718722],"genre_scores_gemma":[0.9630294,0.01092014,0.01515123,0.00007531581,0.00002510942,0.0003085952,0.003811411,0.00003337644,0.006645462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002221201,"threshold_uncertainty_score":0.004416585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207063430290164,"score_gpt":0.2561440472882886,"score_spread":0.244073412985387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}