{"id":"W4229371045","doi":"10.3390/molecules27093019","title":"Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Associazione Italiana per la Ricerca sul Cancro; Fondazione Italiana per la Ricerca sul Cancro; Canadian Institutes of Health Research; Ministero dell’Istruzione, dell’Università e della Ricerca; Università di Pisa; GlaxoSmithKline","keywords":"Chemistry; Neuroblastoma; In vitro; Cancer cell; Cannabinoid receptor; Cannabinoid; Cannabinoid receptor type 2; Cell culture; Viability assay; Pharmacology; Cancer; Cancer research; Receptor; Biochemistry; Biology; Agonist; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002856074,0.0001270113,0.000162207,0.00005652655,0.00008430402,0.000008600672,0.0001050078,0.00007592802,0.0001141663],"category_scores_gemma":[0.0001072184,0.0001187122,0.00004492651,0.0001486885,0.0000478224,0.000003722807,0.0001438882,0.0001040273,0.000001115714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006386897,"about_ca_system_score_gemma":0.00007047496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001771867,"about_ca_topic_score_gemma":0.0000049776,"domain_scores_codex":[0.9987549,0.0004044307,0.0001692447,0.0003313513,0.000158188,0.0001818384],"domain_scores_gemma":[0.9996763,0.00002206182,0.0001091233,0.00008718606,0.00006295048,0.0000423064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004168407,0.0000966493,0.0000744121,0.00001088416,0.00001806286,0.000001686353,0.00003289308,0.000359001,0.9888631,0.000004469344,0.0001063009,0.01001567],"study_design_scores_gemma":[0.0003111853,0.0002569201,0.002885506,0.000006366992,0.00001155479,0.000001206947,0.0000274423,0.001189749,0.9939234,0.00001697979,0.001239508,0.0001301626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987907,0.0002521671,0.00009830748,0.0001149608,0.0001578706,0.0003643888,0.0001616714,0.000008253071,0.00005166909],"genre_scores_gemma":[0.998315,0.0004568383,0.00009421381,0.0003482483,0.00004025159,0.0005385448,0.0001768585,0.00001310958,0.00001697092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009885509,"threshold_uncertainty_score":0.4840943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207063430290164,"score_gpt":0.2561440472882886,"score_spread":0.244073412985387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}