{"id":"W4229372493","doi":"10.1128/jvi.00335-22","title":"Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"California NanoSystems Institute; National Center for Research Resources; National Institute of General Medical Sciences; National Science Foundation; National Institutes of Health; International Centre for Bamboo and Rattan; Florida State University","keywords":"Capsid; Antigenicity; Biology; Virology; Adeno-associated virus; Virus; Genetics; Antibody; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003817129,0.00007792216,0.0001611707,0.00006915297,0.000166586,0.00000684033,0.0002383525,0.00006156112,0.0003897057],"category_scores_gemma":[0.0001080384,0.00006158116,0.00008613987,0.000125934,0.00008795031,0.000006107568,0.0001908461,0.0003592221,4.5056e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002949676,"about_ca_system_score_gemma":0.0001043906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001085687,"about_ca_topic_score_gemma":0.0001364685,"domain_scores_codex":[0.9987686,0.0005172029,0.0002937226,0.0001135067,0.0001733251,0.0001336071],"domain_scores_gemma":[0.9992049,0.00001901599,0.0004500194,0.0001575024,0.000129326,0.00003920132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001242721,0.00008866395,0.004048675,0.000003229592,0.0001296123,0.000001314039,0.00008821957,0.00007633518,0.9935834,0.000002703902,0.0002714145,0.000463643],"study_design_scores_gemma":[0.0006580846,0.002059064,0.03643313,0.00000331936,0.00002547213,0.00009891131,0.00004000138,0.0000386306,0.9530277,0.00003441352,0.00752006,0.00006118721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983038,0.0002432195,0.00003658693,0.0007898666,0.000400504,0.00009292717,0.0001237293,0.000001460325,0.000007947418],"genre_scores_gemma":[0.9991052,0.0002174547,0.00002127274,0.0003333458,0.000115376,0.00000243452,0.00004149335,0.00001179177,0.0001517037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04055575,"threshold_uncertainty_score":0.4267004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00929329471345237,"score_gpt":0.2657562389566095,"score_spread":0.2564629442431571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}