{"id":"W4229375798","doi":"10.1101/gr.276363.121","title":"Early embryonic mutations reveal dynamics of somatic and germ cell lineages in mice","year":2022,"lang":"en","type":"article","venue":"Genome Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Natural Science Center for Basic Research and Development, Hiroshima University; U.S. Department of Energy","keywords":"Biology; Somatic cell; Genetics; Germ cell; Embryonic stem cell; Mutation; Zygote; Germline; Lineage (genetic); Embryo; Gene; Embryogenesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002061324,0.0002775484,0.0001810714,0.0006741767,0.0001302302,0.0003195419,0.0002237692,0.0003971815,0.0006443344],"category_scores_gemma":[0.000246369,0.0003379902,0.0002269862,0.0001967737,0.0002208326,0.0002221068,0.0002861093,0.0005640372,0.0002297493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001874207,"about_ca_system_score_gemma":0.0001096486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004654293,"about_ca_topic_score_gemma":0.001000221,"domain_scores_codex":[0.9998766,0.00001551917,0.00001223346,0.00003548653,0.00003931894,0.00002070714],"domain_scores_gemma":[0.9997544,0.00006432081,0.00009586507,0.00003026521,0.00001688866,0.00003829919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005216925,0.000006068623,0.001473341,0.00001395667,0.000007591967,0.00005604945,0.00002641148,0.0002289533,0.9954556,0.0002177937,0.00001307608,0.002448921],"study_design_scores_gemma":[0.0000185602,0.000180964,0.05664641,0.00002184658,0.00005162829,0.001164813,0.00004164841,0.005104138,0.933859,0.0005147033,0.002379923,0.00001624765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821324,0.0006699812,0.01565425,0.00003489163,0.000006922085,0.00001225248,0.000452026,0.0002104953,0.0008268723],"genre_scores_gemma":[0.9761704,0.0007817271,0.01996962,0.00005844481,0.000005842544,0.00002799075,0.0005808577,0.0001897343,0.002215459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006741767,"threshold_uncertainty_score":0.002155483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853272826480526,"score_gpt":0.3053621465621291,"score_spread":0.2868294182973238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}