{"id":"W4229375798","doi":"10.1101/gr.276363.121","title":"Early embryonic mutations reveal dynamics of somatic and germ cell lineages in mice","year":2022,"lang":"en","type":"article","venue":"Genome Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Natural Science Center for Basic Research and Development, Hiroshima University; U.S. Department of Energy","keywords":"Biology; Somatic cell; Genetics; Germ cell; Embryonic stem cell; Mutation; Zygote; Germline; Lineage (genetic); Embryo; Gene; Embryogenesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006750347,0.00006724762,0.0001096478,0.0001531044,0.000126966,0.00001961072,0.0001939695,0.0000449117,0.00002514271],"category_scores_gemma":[0.00009837368,0.00007838289,0.0000320144,0.0002367261,0.00009710668,0.000001831356,0.0004373887,0.0002100097,0.000003168677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007928799,"about_ca_system_score_gemma":0.0002437332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002534543,"about_ca_topic_score_gemma":0.0002113544,"domain_scores_codex":[0.9989958,0.0001382388,0.0001798167,0.0002272046,0.0002009356,0.0002580181],"domain_scores_gemma":[0.9995013,0.00009222704,0.00004869337,0.0002154699,0.00008332972,0.0000589633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001039955,0.0002345975,0.01523494,0.000200806,0.00003014324,0.00001770571,0.0007741354,0.001694203,0.9792717,0.0003994319,0.0003414978,0.001696851],"study_design_scores_gemma":[0.01054592,0.009425705,0.6332607,0.00009889425,0.000113823,0.0001605665,0.01530354,0.01070426,0.2621565,0.01110443,0.04493154,0.00219416],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995487,0.002924109,0.00005351864,0.0002629127,0.00003423712,0.0002280075,0.0001730802,0.000002002747,0.0008351582],"genre_scores_gemma":[0.9975783,0.0006425768,0.0003188777,0.00002171122,0.00004720747,0.00006323677,0.0001658164,0.0000164221,0.001145912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7171152,"threshold_uncertainty_score":0.3196362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853272826480526,"score_gpt":0.3053621465621291,"score_spread":0.2868294182973238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}