{"id":"W4229376400","doi":"10.3389/fneur.2022.852003","title":"Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies","year":2022,"lang":"en","type":"review","venue":"Frontiers in Neurology","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Krembil Foundation; University of Toronto; Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research; Rossy Foundation; Weston Brain Institute","keywords":"Synucleinopathies; Alpha-synuclein; Dementia with Lewy bodies; Parkinson's disease; Neuroscience; Medicine; Neuroinflammation; Blood–brain barrier; Dementia; Disease; Biology; Pathology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004018791,0.0008324487,0.0009781189,0.001709294,0.0001904954,0.0006059088,0.0006250175,0.000994865,0.002603624],"category_scores_gemma":[0.0003409479,0.0001845136,0.0004314842,0.001118402,0.0002914534,0.0007290696,0.0004710515,0.00154091,0.00180955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003941414,"about_ca_system_score_gemma":0.0004988451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004920111,"about_ca_topic_score_gemma":0.001155261,"domain_scores_codex":[0.9998893,0.00001769264,0.00001234944,0.00001709653,0.00005005396,0.00001353278],"domain_scores_gemma":[0.9998909,0.00004700126,0.00001705773,0.000003260876,0.00002826579,0.00001351245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001062597,0.0001556607,0.00009435,0.01721255,0.00009846541,0.0002815135,0.0000616997,0.0004991039,0.009507114,0.003799137,0.02317932,0.9450049],"study_design_scores_gemma":[0.00004679207,0.000266023,0.0007382429,0.002901759,0.0001535586,0.001590128,0.00004188814,0.0001781886,0.001973109,0.001811724,0.9902794,0.00001917175],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002694611,0.9981136,0.0001973856,0.0001460895,0.000188056,0.000008987519,0.00001754423,0.00001269898,0.001046],"genre_scores_gemma":[0.001343758,0.9971403,0.0003104179,0.00015237,0.000109499,0.00001308135,0.00003484946,0.00000230963,0.0008934629],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002603624,"threshold_uncertainty_score":0.008709967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05065073403962703,"score_gpt":0.2953315203525574,"score_spread":0.2446807863129304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}