{"id":"W4229439227","doi":"10.1093/hmg/ddac105","title":"Developmental disruption to the cortical transcriptome and synaptosome in a model of <i>SETD1A</i> loss-of-function","year":2022,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Wellcome Trust","keywords":"Biology; Transcriptome; Epigenetics; Genetics; DNA methylation; Gene; Histone; Gene expression profiling; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135124,0.0004745615,0.00025373,0.001018722,0.0004450517,0.0004663319,0.0005364489,0.0005673149,0.002497754],"category_scores_gemma":[0.0001935532,0.0003268683,0.0005110978,0.000336971,0.000772147,0.000226846,0.0005611299,0.001086985,0.0003939962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009529146,"about_ca_system_score_gemma":0.0005615556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003777234,"about_ca_topic_score_gemma":0.009144861,"domain_scores_codex":[0.9997309,0.0000274152,0.00002445435,0.00009823015,0.00007961181,0.00003946332],"domain_scores_gemma":[0.9996701,0.00004962676,0.0001202274,0.00003944993,0.00002126322,0.00009938865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001223266,0.00003588537,0.0004144344,0.00002370609,0.00001374025,0.0001295594,0.0000256512,0.0001788421,0.9978175,0.0003196556,0.00008162633,0.0008370552],"study_design_scores_gemma":[0.00004189362,0.0003439871,0.02124831,0.00001877544,0.00005894013,0.000817474,0.0001267194,0.003011042,0.9704029,0.0003808549,0.003526919,0.00002218313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984632,0.0005339932,0.009417499,0.0003115415,0.00008733843,0.00007123427,0.00278871,0.0002877254,0.001869964],"genre_scores_gemma":[0.9828559,0.0005778773,0.00829126,0.0002041892,0.000006984651,0.0001571333,0.001185499,0.0001412591,0.006579799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003777234,"threshold_uncertainty_score":0.008355856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851854325658452,"score_gpt":0.2597984749630947,"score_spread":0.2412799317065101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}