{"id":"W4229444575","doi":"10.1002/jha2.455","title":"Transcriptional profiles define drug refractory disease in myeloma","year":2022,"lang":"en","type":"article","venue":"eJHaem","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"Multiple myeloma; Lenalidomide; Medicine; Internal medicine; Refractory (planetary science); Oncology; Drug resistance; Disease; Gene expression profiling; Drug; Carfilzomib; Gene; Gene expression; Cancer research; Biology; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001525559,0.0001075179,0.0001589769,0.000167275,0.0001278385,0.000007818426,0.00008313421,0.00001429461,0.002588629],"category_scores_gemma":[0.00006036606,0.00009566724,0.00008310926,0.0002055157,0.00004313646,0.00005984959,0.00005294123,0.0002745771,0.0000885996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002410703,"about_ca_system_score_gemma":0.0002378683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001175952,"about_ca_topic_score_gemma":0.00003346819,"domain_scores_codex":[0.9986788,0.00009736319,0.0001625183,0.0002452079,0.0005336831,0.0002824161],"domain_scores_gemma":[0.9994274,0.00004646545,0.00002368448,0.0002097389,0.00002520038,0.0002674982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004598212,0.00304814,0.9437078,0.000183783,0.0001310102,0.005152419,0.001166209,0.00004850584,0.006106057,0.002072781,0.009041899,0.02474322],"study_design_scores_gemma":[0.003512118,0.0001740758,0.9570822,0.00002609308,0.00002201567,0.00002304155,0.0001775363,0.0003869963,0.0002450868,0.0003160952,0.03793413,0.0001006497],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924955,0.001469576,0.000004824456,0.00258027,0.0000980594,0.0005048346,0.0001562963,0.00005089404,0.002639757],"genre_scores_gemma":[0.993683,0.0000243653,0.0002398833,0.0002306381,0.00008064978,0.0003688289,0.0004146547,0.0000194907,0.00493851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02889223,"threshold_uncertainty_score":0.9983231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02663950204685158,"score_gpt":0.2924291734670066,"score_spread":0.265789671420155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}