{"id":"W4229444575","doi":"10.1002/jha2.455","title":"Transcriptional profiles define drug refractory disease in myeloma","year":2022,"lang":"en","type":"article","venue":"eJHaem","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"Multiple myeloma; Lenalidomide; Medicine; Internal medicine; Refractory (planetary science); Oncology; Drug resistance; Disease; Gene expression profiling; Drug; Carfilzomib; Gene; Gene expression; Cancer research; Biology; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002038205,0.000107652,0.0002206167,0.0006368164,0.00013712,0.0003011585,0.00007260168,0.000185403,0.0008218188],"category_scores_gemma":[0.000332873,0.00007495565,0.0001606435,0.000645705,0.0001774351,0.0001029758,0.0001496101,0.00015612,0.000157478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002533143,"about_ca_system_score_gemma":0.0001225423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000965204,"about_ca_topic_score_gemma":0.0009450503,"domain_scores_codex":[0.9998845,0.00002815009,0.000006721281,0.00003178403,0.0000249417,0.0000239238],"domain_scores_gemma":[0.9998358,0.00005293624,0.00006095806,0.00001528318,0.00001904171,0.00001593839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00121564,0.0001091423,0.798197,0.00006902905,0.00009725423,0.0001705625,0.00026716,0.002528365,0.1793568,0.0003744913,0.0003627083,0.01725181],"study_design_scores_gemma":[0.00001117321,0.0002420752,0.9825196,0.000007284337,0.00003678325,0.0002612347,0.0002526657,0.005132041,0.01006686,0.0004622512,0.001001514,0.000006455387],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980064,0.0002668894,0.0006327916,0.0000219035,0.000002011643,0.000009405432,0.0007005273,0.00001107375,0.0003489166],"genre_scores_gemma":[0.9983398,0.0001035499,0.0004276671,0.00002397379,0.000004162942,0.00001532137,0.0008784027,0.000002531231,0.0002045807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000965204,"threshold_uncertainty_score":0.002749264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02663950204685158,"score_gpt":0.2924291734670066,"score_spread":0.265789671420155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}