{"id":"W4229449592","doi":"10.1371/journal.ppat.1010494","title":"Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Stiftelsen Läkare mot AIDS Forskningsfond; Science for Life Laboratory; Vetenskapsrådet; Karolinska Institutet; Canadian Institutes of Health Research; Ragon Institute of MGH, MIT and Harvard; Stiftelsen Olle Engkvist Byggmästare; Knut och Alice Wallenbergs Stiftelse","keywords":"Biology; Immune system; Transcriptome; Immunology; Downregulation and upregulation; Medroxyprogesterone acetate; Epithelium; Andrology; Gene expression; Hormone; Medicine; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008670872,0.0001219307,0.0004547522,0.0003223047,0.0002713412,0.000004223276,0.0003944213,0.00009256727,0.0006656137],"category_scores_gemma":[0.0003735498,0.00009386353,0.0002504479,0.001211136,0.0003544579,0.00004051457,0.0005135739,0.0006635124,0.00001000335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003129088,"about_ca_system_score_gemma":0.0001515955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00018997,"about_ca_topic_score_gemma":0.00004383947,"domain_scores_codex":[0.9978189,0.0009891157,0.0003920504,0.0003191259,0.0001223396,0.0003584239],"domain_scores_gemma":[0.99874,0.0001629387,0.0002321716,0.0006499733,0.0001907218,0.00002416525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001087098,0.0008122867,0.1294177,0.00001876664,0.002047386,0.00000168946,0.001665492,0.001357215,0.8642476,0.00003446697,0.000001570139,0.0002870756],"study_design_scores_gemma":[0.0007344505,0.0002006619,0.320737,0.00000599882,0.0009153167,0.00003436708,0.001517113,0.00168688,0.673763,0.00003320454,0.0002275973,0.0001444485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983886,0.0001657076,0.0001697741,0.00008255602,0.0002134963,0.000320305,0.0006177131,0.00001777202,0.00002407316],"genre_scores_gemma":[0.9992996,0.00001111604,0.0004128214,0.00001613044,0.00001087306,0.00006346335,0.00003376188,0.00001494903,0.0001372766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1913193,"threshold_uncertainty_score":0.7288004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05815609035720651,"score_gpt":0.3036847409434574,"score_spread":0.2455286505862509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}