{"id":"W4229449592","doi":"10.1371/journal.ppat.1010494","title":"Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Stiftelsen Läkare mot AIDS Forskningsfond; Science for Life Laboratory; Vetenskapsrådet; Karolinska Institutet; Canadian Institutes of Health Research; Ragon Institute of MGH, MIT and Harvard; Stiftelsen Olle Engkvist Byggmästare; Knut och Alice Wallenbergs Stiftelse","keywords":"Biology; Immune system; Transcriptome; Immunology; Downregulation and upregulation; Medroxyprogesterone acetate; Epithelium; Andrology; Gene expression; Hormone; Medicine; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005981344,0.0005443754,0.001367524,0.002069052,0.0006665841,0.001319071,0.0003387825,0.000754799,0.001650792],"category_scores_gemma":[0.0009426218,0.0002039934,0.001305402,0.002282507,0.0002287011,0.0003331752,0.0008512837,0.0005552192,0.0007524054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004248309,"about_ca_system_score_gemma":0.0005306848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003253351,"about_ca_topic_score_gemma":0.004323128,"domain_scores_codex":[0.9994121,0.00009159266,0.00004990913,0.0001821489,0.000132149,0.0001321773],"domain_scores_gemma":[0.999487,0.0001750187,0.000113203,0.00006912152,0.0001159366,0.00003969149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003581248,0.0003355702,0.4401231,0.003194065,0.001954072,0.00152326,0.0008417427,0.003828713,0.4525439,0.0006245352,0.007198431,0.08425129],"study_design_scores_gemma":[0.0000351293,0.0004229959,0.9391072,0.0003218153,0.001147502,0.001550162,0.001836246,0.008674447,0.02498414,0.001071964,0.02077709,0.00007125521],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.890627,0.01316375,0.005392123,0.001135006,0.0001079561,0.0001326248,0.08511546,0.0003201694,0.004005899],"genre_scores_gemma":[0.8906374,0.005613082,0.01336755,0.0009822513,0.00009928085,0.0003650512,0.08644793,0.00009586148,0.002391658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003253351,"threshold_uncertainty_score":0.006468832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05815609035720651,"score_gpt":0.3036847409434574,"score_spread":0.2455286505862509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}