{"id":"W4229451358","doi":"10.2217/cer-2021-0278","title":"Channeling effects in the prescription of new therapies: the case of emicizumab for hemophilia A","year":2022,"lang":"en","type":"article","venue":"Journal of Comparative Effectiveness Research","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Medical prescription; Health insurance; Health care; Pediatrics; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009357636,0.0001295923,0.0006369472,0.0005579021,0.0003085556,0.00001798035,0.000374705,0.00004410384,0.00002826068],"category_scores_gemma":[0.0005299762,0.00006508387,0.0002570862,0.001040046,0.0002634882,0.00009143948,0.0001044208,0.0009931519,7.001825e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716916,"about_ca_system_score_gemma":0.0006053351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001627904,"about_ca_topic_score_gemma":0.00001845204,"domain_scores_codex":[0.9940734,0.003943834,0.0004727932,0.0001551953,0.001038095,0.0003166866],"domain_scores_gemma":[0.9905355,0.007988975,0.000241311,0.0002721465,0.0008862903,0.00007576191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.113751,0.008831084,0.054235,0.00787422,0.004248478,0.006512833,0.2389405,0.01091983,0.4814745,0.01196425,0.006098339,0.05515002],"study_design_scores_gemma":[0.05690793,0.08102197,0.24576,0.004356998,0.0006419832,0.01206957,0.1179593,0.01918149,0.403739,0.05432313,0.003469401,0.0005692113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915621,0.003549969,0.0006825655,0.001083525,0.0001141762,0.002852195,0.000007208824,0.000002029703,0.0001462391],"genre_scores_gemma":[0.9993082,0.00006484801,0.0001059327,0.00001289275,0.0001723239,0.0002262843,0.000002489878,0.00001279629,0.00009418128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.191525,"threshold_uncertainty_score":0.4314806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1627061552598147,"score_gpt":0.464600125679324,"score_spread":0.3018939704195093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}