{"id":"W4229451525","doi":"10.1208/s12249-022-02294-w","title":"Optimization of DOTAP/chol Cationic Lipid Nanoparticles for mRNA, pDNA, and Oligonucleotide Delivery","year":2022,"lang":"en","type":"article","venue":"AAPS PharmSciTech","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"National Institute of General Medical Sciences; Binghamton University; National Institutes of Health","keywords":"Transfection; PEGylation; Chemistry; Oligonucleotide; Nucleic acid; Gene delivery; Messenger RNA; Molecular biology; Biophysics; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645293,0.00009650958,0.0001055551,0.00005535,0.0001530832,0.00001696319,0.0001629928,0.00003900348,0.00007043751],"category_scores_gemma":[0.00002950635,0.0001044161,0.00005874049,0.00009876672,0.00004955937,0.000009398908,0.0001520107,0.0000521616,0.000001666042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001388736,"about_ca_system_score_gemma":0.00004899778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002503013,"about_ca_topic_score_gemma":0.000006421431,"domain_scores_codex":[0.9992529,0.00003621822,0.0001968288,0.0002567484,0.00009924466,0.0001580257],"domain_scores_gemma":[0.9995523,0.00001523216,0.00009456906,0.0001956785,0.00009873688,0.00004347431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001383205,0.00006711113,0.0007369748,0.00001982896,0.00004025571,5.584438e-7,0.00007431253,0.0101115,0.9825786,0.00005008871,0.002566311,0.003616128],"study_design_scores_gemma":[0.0007671744,0.0005283218,0.0003184251,0.000006763571,0.00003764918,0.00001618363,0.0001785514,0.003369718,0.9810408,0.0000889184,0.01347664,0.0001708241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967195,0.00073193,0.001772613,0.0001620003,0.0001409724,0.0002477478,0.00008104339,0.00001125597,0.0001329441],"genre_scores_gemma":[0.9970514,0.0003598928,0.001549786,0.0003163239,0.00008730515,0.0001159391,0.0001508318,0.00001702254,0.0003514748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01091033,"threshold_uncertainty_score":0.4257965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172467703047005,"score_gpt":0.2463721332121306,"score_spread":0.2346474561816605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}