{"id":"W4229452091","doi":"10.1038/s41587-022-01316-z","title":"An open invitation to the Understudied Proteins Initiative","year":2022,"lang":"en","type":"letter","venue":"Nature Biotechnology","topic":"Genetics, Bioinformatics, and Biomedical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Francis Crick Institute; Wellcome Trust; Wellcome","keywords":"Computational biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009084574,0.001142629,0.001473767,0.0007640251,0.006505931,0.007088983,0.002193387,0.06087285,0.006991857],"category_scores_gemma":[0.02914393,0.0007546548,0.00165366,0.0005621197,0.005530287,0.004880589,0.004606267,0.06363314,0.007208477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003655733,"about_ca_system_score_gemma":0.005330921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0024047,"about_ca_topic_score_gemma":0.005059245,"domain_scores_codex":[0.9927425,0.001368344,0.000389929,0.0009010933,0.003524597,0.001073484],"domain_scores_gemma":[0.9820219,0.009098424,0.0008375364,0.0007679058,0.001974359,0.005299932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004023532,0.00003068851,0.00008784146,0.00001655875,0.000009859074,0.0003218345,0.00006038153,0.00001876515,0.000160813,0.00351286,0.992102,0.003638205],"study_design_scores_gemma":[0.000108172,0.00004786029,0.0005099925,0.00006658935,0.00001746906,0.0002988842,0.0002331231,0.0002115953,0.0003095825,0.01340974,0.9847324,0.00005450861],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.0002239817,0.0008792266,0.0002340073,0.9548091,0.04093778,0.0000140172,0.00004337556,0.00003905533,0.002819451],"genre_scores_gemma":[0.001734519,0.0003177184,0.0002409213,0.9636362,0.02393522,0.00003629879,0.00002377191,0.00004532578,0.01003002],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.06087285,"threshold_uncertainty_score":0.04804438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0275585040008973,"score_gpt":0.3242378879490688,"score_spread":0.2966793839481714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}