{"id":"W4229453248","doi":"10.1016/j.taap.2022.116055","title":"Identification of novel and potential PPARγ stimulators as repurposed drugs for MCAO associated brain degeneration","year":2022,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Neuroprotection; Pharmacology; Medicine; Drug repositioning; Peroxisome proliferator-activated receptor; Receptor; Internal medicine; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715455,0.0004127552,0.0006181007,0.0007467467,0.0003243437,0.0003934838,0.0003226468,0.0003340463,0.003301622],"category_scores_gemma":[0.0001443269,0.0001525296,0.0004167097,0.0003122027,0.0002709797,0.0003707976,0.0002723397,0.0007405028,0.0004520706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002313593,"about_ca_system_score_gemma":0.0004018724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003481124,"about_ca_topic_score_gemma":0.001442601,"domain_scores_codex":[0.9999434,0.00001169605,0.000005692722,0.00001129607,0.00001389761,0.00001391426],"domain_scores_gemma":[0.999927,0.000009849892,0.00002081602,0.000007074086,0.00001826718,0.00001696522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002084143,0.0008039767,0.001285695,0.0009890629,0.0001172844,0.001186665,0.0001044594,0.0002772656,0.9159276,0.001564332,0.0006290288,0.07503045],"study_design_scores_gemma":[0.0007205656,0.01035285,0.0187608,0.0002831992,0.0008282479,0.00446044,0.0003427086,0.001945157,0.905008,0.001829091,0.05539027,0.00007866235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9056855,0.07171889,0.01123528,0.001073036,0.0002076233,0.0004168442,0.0008082242,0.0002833455,0.00857121],"genre_scores_gemma":[0.9373276,0.04352949,0.0101967,0.0004650698,0.0001335689,0.0002028293,0.0007757134,0.00002891336,0.007340075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003301622,"threshold_uncertainty_score":0.01104504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009277100430573445,"score_gpt":0.2801830392196191,"score_spread":0.2709059387890456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}