{"id":"W4229454042","doi":"10.1208/s12248-022-00707-z","title":"Biomarker Assay Validation by Mass Spectrometry","year":2022,"lang":"en","type":"article","venue":"The AAPS Journal","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Native Health Society","funders":"","keywords":"Biomarker; Bioanalysis; Context (archaeology); Biomarker discovery; Computational biology; Chemistry; Chromatography; Proteomics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002481764,0.00009149067,0.0001336775,0.00007130679,0.000763748,0.00003664264,0.0003553306,0.00006561575,0.01391692],"category_scores_gemma":[0.00009126333,0.00005503949,0.0001127495,0.0002391881,0.0001156814,0.00004167321,0.0001080411,0.0007794001,0.00008265093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006712562,"about_ca_system_score_gemma":0.00002780671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004044928,"about_ca_topic_score_gemma":1.362701e-7,"domain_scores_codex":[0.9980875,0.001252656,0.000210091,0.0001162674,0.00007438364,0.0002591081],"domain_scores_gemma":[0.9994525,0.0002013559,0.0001273749,0.0001673131,0.0000283672,0.00002308842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008021186,0.00005558564,0.0004276218,9.292123e-7,0.0001678068,0.000006117798,0.00003281367,0.000001339199,0.7884549,0.0003395295,0.2033436,0.007089525],"study_design_scores_gemma":[0.001030908,0.0003427123,0.002463686,0.000004919128,0.0001555202,0.001963767,0.0004715866,0.00002996273,0.1787097,0.009007047,0.80559,0.000230205],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.478198,0.06011084,0.1918712,0.171466,0.02163699,0.001147505,0.0007089508,0.0003461341,0.0745144],"genre_scores_gemma":[0.981807,0.000159144,0.001439895,0.001654503,0.0001092743,0.000006097748,0.00002518265,0.00001612312,0.01478278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6097453,"threshold_uncertainty_score":0.9869845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409107912245526,"score_gpt":0.2840727474356391,"score_spread":0.2599816683131838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}