{"id":"W4229454042","doi":"10.1208/s12248-022-00707-z","title":"Biomarker Assay Validation by Mass Spectrometry","year":2022,"lang":"en","type":"article","venue":"The AAPS Journal","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Native Health Society","funders":"","keywords":"Biomarker; Bioanalysis; Context (archaeology); Biomarker discovery; Computational biology; Chemistry; Chromatography; Proteomics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04829776,0.003225049,0.002423866,0.01084553,0.002209368,0.005648281,0.003582756,0.005388916,0.005939245],"category_scores_gemma":[0.06269796,0.001439717,0.003085701,0.004049521,0.003696411,0.004383236,0.004514079,0.003938985,0.01073876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002333643,"about_ca_system_score_gemma":0.008255896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002750761,"about_ca_topic_score_gemma":0.002728733,"domain_scores_codex":[0.9259229,0.01964558,0.005591871,0.009294342,0.03802828,0.001516996],"domain_scores_gemma":[0.9593825,0.009701924,0.00510887,0.005943373,0.019253,0.0006101384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001043602,0.0007190345,0.02477756,0.008567867,0.001635659,0.001422242,0.001484097,0.00434786,0.4728753,0.03354704,0.0599517,0.3896281],"study_design_scores_gemma":[0.0001169697,0.0008705731,0.01074934,0.002421289,0.0005572956,0.002551254,0.0004113818,0.0133737,0.5315811,0.01521923,0.4217148,0.0004330149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03698411,0.05028764,0.8355832,0.007462062,0.005848587,0.004480073,0.00884298,0.00846102,0.04205037],"genre_scores_gemma":[0.1949765,0.04390071,0.6931185,0.01289915,0.00220766,0.00645741,0.01502035,0.002816084,0.0286036],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.04829776,"threshold_uncertainty_score":0.255426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409107912245526,"score_gpt":0.2840727474356391,"score_spread":0.2599816683131838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}