{"id":"W4229454790","doi":"10.1159/000523734","title":"Complex Germline K757N Mutation in Non-Small-Cell Lung Cancer: A Case Report","year":2022,"lang":"en","type":"article","venue":"Case Reports in Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Medicine; Germline mutation; Lung cancer; Germline; Oncology; Epidermal growth factor receptor; Mutation; Cancer research; Targeted therapy; Pembrolizumab; Carboplatin; Cancer; Internal medicine; Genetics; Biology; Chemotherapy; Immunotherapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005853299,0.0001716467,0.0004857513,0.0003470951,0.0001723374,0.000007562223,0.00002550158,0.00009684639,0.000726942],"category_scores_gemma":[0.00008794905,0.0001745098,0.00008117576,0.0004891888,0.00005237111,0.00004847285,0.00008692821,0.0003797814,0.000001350404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003036141,"about_ca_system_score_gemma":0.001654456,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01030394,"about_ca_topic_score_gemma":0.007917891,"domain_scores_codex":[0.9979246,0.0001089322,0.0009479023,0.0005236923,0.000173657,0.0003212661],"domain_scores_gemma":[0.9987501,0.0001099603,0.0004864201,0.0004191008,0.0001029886,0.0001314529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00007692842,0.0008233244,0.04369171,0.00009756264,0.00006171571,0.9415984,0.002453902,0.002383527,0.0002154734,0.000008074082,0.001589068,0.007000325],"study_design_scores_gemma":[0.002811662,0.0004047003,0.006764382,0.00002993143,0.0002962077,0.967007,0.002247174,0.002860443,0.00006736772,0.00003481939,0.01732251,0.000153729],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862616,0.0008479316,0.00008070844,0.001092165,0.0007957781,0.001405899,0.00002890371,0.00004121896,0.009445781],"genre_scores_gemma":[0.994603,0.00003765982,0.0009988295,0.0005575326,0.0001267778,0.001493653,0.0003163719,0.00003241039,0.00183378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03692733,"threshold_uncertainty_score":0.9962865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02735207391141033,"score_gpt":0.3966273898230287,"score_spread":0.3692753159116184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}