{"id":"W4229456253","doi":"10.1172/jci.insight.150363","title":"MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Stichting Kinderen Kankervrij; KWF Kankerbestrijding; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit Leiden; Leids Universitair Medisch Centrum; AstraZeneca","keywords":"MEF2C; Cancer research; Progenitor cell; CD19; Biology; Cellular differentiation; Cell biology; Downregulation and upregulation; Ectopic expression; Stem cell; Leukemia; GATA3; T cell; Immunology; Cell culture; Antigen; Gene expression; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112511,0.0002122781,0.0001355364,0.0002929427,0.0001886035,0.0004906621,0.0002240288,0.0002427299,0.002134954],"category_scores_gemma":[0.00012161,0.0001331534,0.0001107366,0.0001229,0.0002955387,0.0001690661,0.0002640228,0.0005652614,0.0005876833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003788128,"about_ca_system_score_gemma":0.0002739282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000620276,"about_ca_topic_score_gemma":0.001831013,"domain_scores_codex":[0.9997984,0.00004227517,0.00001636221,0.00003576563,0.0000588817,0.00004841846],"domain_scores_gemma":[0.9998705,0.00001998114,0.00002887877,0.00001900333,0.00001297774,0.00004857681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004302878,0.000008328117,0.0002445685,0.0000140956,0.000001857685,0.00004339361,0.000006374279,0.0000504853,0.9983878,0.0002337201,0.0000390682,0.0009271484],"study_design_scores_gemma":[0.00003060326,0.00009253103,0.004784602,0.00001096446,0.000009595201,0.0004943357,0.00003041977,0.001542266,0.9871415,0.0001045666,0.005755603,0.000003004253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897453,0.001592221,0.003144916,0.0001934393,0.00003809546,0.0000199607,0.0003922449,0.0001112695,0.00476258],"genre_scores_gemma":[0.9949597,0.0003734322,0.00106265,0.00004185851,0.000009659875,0.00001225909,0.0002108584,0.00002645258,0.003303073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002134954,"threshold_uncertainty_score":0.007142127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01814676427419847,"score_gpt":0.2887302397502326,"score_spread":0.2705834754760341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}