{"id":"W4229456253","doi":"10.1172/jci.insight.150363","title":"MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Stichting Kinderen Kankervrij; KWF Kankerbestrijding; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit Leiden; Leids Universitair Medisch Centrum; AstraZeneca","keywords":"MEF2C; Cancer research; Progenitor cell; CD19; Biology; Cellular differentiation; Cell biology; Downregulation and upregulation; Ectopic expression; Stem cell; Leukemia; GATA3; T cell; Immunology; Cell culture; Antigen; Gene expression; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007455278,0.0001858089,0.0003361853,0.0004170791,0.0001670418,0.00004454082,0.0003532088,0.00009392155,0.000235527],"category_scores_gemma":[0.0004963735,0.0001251234,0.00005730637,0.0008697465,0.0001295816,0.0001172413,0.0004576826,0.0005701917,0.00002565993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002134367,"about_ca_system_score_gemma":0.00113793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004838286,"about_ca_topic_score_gemma":0.0002149543,"domain_scores_codex":[0.997707,0.0002500757,0.0003538589,0.0004124764,0.0008734878,0.0004030934],"domain_scores_gemma":[0.9981664,0.001140382,0.00005928982,0.0004816992,0.00004216974,0.0001100545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0129292,0.003919142,0.2592751,0.0007909523,0.0003629977,0.03439144,0.1280441,0.003737292,0.1083337,0.00942414,0.1452171,0.2935748],"study_design_scores_gemma":[0.03773473,0.002795082,0.2101222,0.0005235357,0.000125448,0.004086241,0.01336598,0.05284038,0.01192941,0.00142439,0.6640124,0.001040179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869237,0.001531863,0.00007859163,0.001586784,0.0001584314,0.000613939,0.00001135258,0.0000304597,0.009064869],"genre_scores_gemma":[0.9955975,0.0005317449,0.0005978968,0.002040762,0.0001452953,0.0001439964,0.00002622049,0.00003050716,0.0008860744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5187953,"threshold_uncertainty_score":0.5581296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01814676427419847,"score_gpt":0.2887302397502326,"score_spread":0.2705834754760341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}