{"id":"W4229458948","doi":"10.21203/rs.3.rs-1499067/v1","title":"Towards In Vivo Proof-of-Binding of 18F-labeled Inhibitor [18F]TRACK to Peripheral Tropomyosin Receptor Kinases","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University; University Health Network","funders":"University of Alberta; Weston Brain Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"In vivo; Kinase; Tropomyosin; Chemistry; Receptor; Cell biology; Molecular biology; Biochemistry; Actin; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006991922,0.0008155447,0.0006283536,0.0002165003,0.0002613044,0.0004759432,0.0008371849,0.0007178775,0.002618393],"category_scores_gemma":[0.0004166196,0.0004453606,0.0004088277,0.0002486676,0.00023208,0.000334219,0.0002395157,0.00076667,0.001211772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004965762,"about_ca_system_score_gemma":0.0003911328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001421892,"about_ca_topic_score_gemma":0.001527371,"domain_scores_codex":[0.99962,0.0001068618,0.00001963598,0.0001254682,0.00006369374,0.00006423445],"domain_scores_gemma":[0.9997298,0.00009685849,0.00005468816,0.0000435707,0.00004544518,0.00002963295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001752645,0.00004282392,0.00007785628,0.00009329256,0.000008368153,0.00005725251,0.00002060562,0.0001953223,0.9979544,0.0001362859,0.0001218926,0.001116722],"study_design_scores_gemma":[0.00003021511,0.0003774345,0.000412973,0.000009571297,0.00001754063,0.0003352783,0.00001237905,0.001489223,0.9939719,0.00002183562,0.003314698,0.000006963147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8793725,0.0064367,0.1033655,0.0003102359,0.0001358405,0.0004764908,0.002039668,0.0005592353,0.007303872],"genre_scores_gemma":[0.9110069,0.003993256,0.07056763,0.0001747033,0.00005624005,0.0004849987,0.002693296,0.0001967517,0.01082622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002618393,"threshold_uncertainty_score":0.008759439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04881611705210007,"score_gpt":0.3819453684335065,"score_spread":0.3331292513814064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}