{"id":"W4229458948","doi":"10.21203/rs.3.rs-1499067/v1","title":"Towards In Vivo Proof-of-Binding of 18F-labeled Inhibitor [18F]TRACK to Peripheral Tropomyosin Receptor Kinases","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University; University Health Network","funders":"University of Alberta; Weston Brain Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"In vivo; Kinase; Tropomyosin; Chemistry; Receptor; Cell biology; Molecular biology; Biochemistry; Actin; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001672841,0.0003573469,0.0005689812,0.000573948,0.0001117881,0.00005004973,0.001045939,0.0003287839,0.00113758],"category_scores_gemma":[0.002012688,0.0003864205,0.0003044866,0.0007859892,0.0002492126,0.000005298768,0.002768942,0.001044454,0.000004800381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003744433,"about_ca_system_score_gemma":0.001616519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003271698,"about_ca_topic_score_gemma":0.00007175269,"domain_scores_codex":[0.9952966,0.0009287301,0.0007023484,0.001041105,0.001294786,0.0007364237],"domain_scores_gemma":[0.9976491,0.0000898475,0.0002131481,0.001132812,0.0006308652,0.0002841942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001262496,0.0007817315,0.005735578,0.001905715,0.00009968922,0.00005142532,0.0005040157,0.001673556,0.9772061,0.00005306511,0.008950548,0.001776116],"study_design_scores_gemma":[0.0007243821,0.001248666,0.0002970763,0.000795518,0.00001317288,0.000002119055,0.0008251402,0.00004182518,0.9845568,0.00008218651,0.01104133,0.0003717963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937387,0.001755821,0.0000389137,0.0002423433,0.0004203654,0.001776381,0.001438965,0.00001833757,0.0005701868],"genre_scores_gemma":[0.9955428,0.0001091349,0.001364987,0.00002148255,0.0004037067,0.0008024624,0.0005799775,0.00009470157,0.001080757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007350728,"threshold_uncertainty_score":0.9998588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04881611705210007,"score_gpt":0.3819453684335065,"score_spread":0.3331292513814064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}